FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897617760> ?p ?o ?g. }

• W2897617760 endingPage "10783" @default.
• W2897617760 startingPage "10774" @default.
• W2897617760 abstract "The penultimate step in the biosynthesis of biotin is the closure of the ureido heterocycle in a reaction requiring a nucleoside triphosphate (NTP). In Mycobacterium tuberculosis this reaction is catalyzed by dethiobiotin synthetase (MtDTBS). MtDTBS is unusual as it can employ multiple (NTPs), with a >100-fold preference for cytidine triphosphate (CTP). Here the molecular basis of NTP binding was investigated using a surface plasmon resonance-based ligand binding assay and X-ray crystallography. The biophysical and structural data revealed two discrete mechanisms by which MtDTBS binds NTPs: (i) A high affinity binding mode employed by CTP (KD 160 nM) that is characterized by a slow dissociation rate between enzyme and ligand (kd 5.3 × 10–2 s–1) and that is defined by an extended network of specific ligand–protein interactions involving both the cytidine and triphosphate moieties and (ii) a low affinity mode employed by the remaining NTPs (KD > 16.5 μM), that is characterized by weak interactions between p..." @default.
• W2897617760 created "2018-10-26" @default.
• W2897617760 creator A5006991971 @default.
• W2897617760 creator A5008559453 @default.
• W2897617760 creator A5013209481 @default.
• W2897617760 creator A5033537928 @default.
• W2897617760 creator A5049711218 @default.
• W2897617760 creator A5059039218 @default.
• W2897617760 creator A5059707193 @default.
• W2897617760 date "2018-10-09" @default.
• W2897617760 modified "2023-09-24" @default.
• W2897617760 title "Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes" @default.
• W2897617760 cites W124504601 @default.
• W2897617760 cites W1743689021 @default.
• W2897617760 cites W1852450713 @default.
• W2897617760 cites W1970563224 @default.
• W2897617760 cites W1993918760 @default.
• W2897617760 cites W1997793435 @default.
• W2897617760 cites W2019879105 @default.
• W2897617760 cites W2044349980 @default.
• W2897617760 cites W2049776409 @default.
• W2897617760 cites W2066812682 @default.
• W2897617760 cites W2078355424 @default.
• W2897617760 cites W2089850803 @default.
• W2897617760 cites W2108804414 @default.
• W2897617760 cites W2108921801 @default.
• W2897617760 cites W2108959691 @default.
• W2897617760 cites W2110035145 @default.
• W2897617760 cites W2122308238 @default.
• W2897617760 cites W2124546624 @default.
• W2897617760 cites W2129143315 @default.
• W2897617760 cites W2129903994 @default.
• W2897617760 cites W2132629607 @default.
• W2897617760 cites W2137190755 @default.
• W2897617760 cites W2144081223 @default.
• W2897617760 cites W2147949826 @default.
• W2897617760 cites W2163341755 @default.
• W2897617760 cites W2180229411 @default.
• W2897617760 cites W2318947213 @default.
• W2897617760 cites W2336504120 @default.
• W2897617760 cites W2343743473 @default.
• W2897617760 cites W2530950373 @default.
• W2897617760 cites W2575298708 @default.
• W2897617760 cites W2585093856 @default.
• W2897617760 cites W2770676136 @default.
• W2897617760 cites W2895241195 @default.
• W2897617760 doi "https://doi.org/10.2210/pdb6cvu/pdb" @default.
• W2897617760 hasPublicationYear "2018" @default.
• W2897617760 type Work @default.
• W2897617760 sameAs 2897617760 @default.
• W2897617760 citedByCount "0" @default.
• W2897617760 crossrefType "component" @default.
• W2897617760 hasAuthorship W2897617760A5006991971 @default.
• W2897617760 hasAuthorship W2897617760A5008559453 @default.
• W2897617760 hasAuthorship W2897617760A5013209481 @default.
• W2897617760 hasAuthorship W2897617760A5033537928 @default.
• W2897617760 hasAuthorship W2897617760A5049711218 @default.
• W2897617760 hasAuthorship W2897617760A5059039218 @default.
• W2897617760 hasAuthorship W2897617760A5059707193 @default.
• W2897617760 hasConcept C104317684 @default.
• W2897617760 hasConcept C106847996 @default.
• W2897617760 hasConcept C107824862 @default.
• W2897617760 hasConcept C116569031 @default.
• W2897617760 hasConcept C155672457 @default.
• W2897617760 hasConcept C170493617 @default.
• W2897617760 hasConcept C171250308 @default.
• W2897617760 hasConcept C181199279 @default.
• W2897617760 hasConcept C185592680 @default.
• W2897617760 hasConcept C192562407 @default.
• W2897617760 hasConcept C2776352584 @default.
• W2897617760 hasConcept C2776543447 @default.
• W2897617760 hasConcept C2781184954 @default.
• W2897617760 hasConcept C512185932 @default.
• W2897617760 hasConcept C55493867 @default.
• W2897617760 hasConcept C71240020 @default.
• W2897617760 hasConceptScore W2897617760C104317684 @default.
• W2897617760 hasConceptScore W2897617760C106847996 @default.
• W2897617760 hasConceptScore W2897617760C107824862 @default.
• W2897617760 hasConceptScore W2897617760C116569031 @default.
• W2897617760 hasConceptScore W2897617760C155672457 @default.
• W2897617760 hasConceptScore W2897617760C170493617 @default.
• W2897617760 hasConceptScore W2897617760C171250308 @default.
• W2897617760 hasConceptScore W2897617760C181199279 @default.
• W2897617760 hasConceptScore W2897617760C185592680 @default.
• W2897617760 hasConceptScore W2897617760C192562407 @default.
• W2897617760 hasConceptScore W2897617760C2776352584 @default.
• W2897617760 hasConceptScore W2897617760C2776543447 @default.
• W2897617760 hasConceptScore W2897617760C2781184954 @default.
• W2897617760 hasConceptScore W2897617760C512185932 @default.
• W2897617760 hasConceptScore W2897617760C55493867 @default.
• W2897617760 hasConceptScore W2897617760C71240020 @default.
• W2897617760 hasIssue "11" @default.
• W2897617760 hasLocation W28976177601 @default.
• W2897617760 hasOpenAccess W2897617760 @default.
• W2897617760 hasPrimaryLocation W28976177601 @default.
• W2897617760 hasRelatedWork W1827647265 @default.
• W2897617760 hasRelatedWork W1852450713 @default.
• W2897617760 hasRelatedWork W1970563224 @default.

• next