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• W2897617954 abstract "Significance Nonalcoholic fatty liver disease (NAFLD) is the fastest rising cause of hepatocellular carcinoma (HCC) in Western countries; however, the molecular mechanisms driving NAFLD-HCC remain elusive. Using Sleeping Beauty transposon mutagenesis in two mouse models of NAFLD-HCC, we identified hundreds of NAFLD-HCC candidate cancer genes that were enriched in pathways often associated with NAFLD and HCC. We also showed that Sav1, which functions in the Hippo signaling pathway and was the most frequently mutated gene identified by SB in both screens, prevents progression of steatohepatitis and subsequent HCC development in coordination with PI3K signaling via suppression of Yap, a downstream effector of the Hippo pathway. Our forward genetic screens have thus identified pathways and genes driving the development of NAFLD-HCC." @default.
• W2897617954 created "2018-10-26" @default.
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• W2897617954 date "2018-10-16" @default.
• W2897617954 modified "2023-10-12" @default.
• W2897617954 title "Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis" @default.
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• W2897617954 doi "https://doi.org/10.1073/pnas.1808968115" @default.
• W2897617954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6217425" @default.
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• W2897617954 hasPublicationYear "2018" @default.
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