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• W2897618879 abstract "MAPT mutations typically cause behavioral variant frontotemporal dementia (bvFTD) with or without parkinsonism. Previous studies have shown that symptomatic MAPT carriers show atrophy in frontotemporal cortex, with mesial temporal lobes predominantly affected (Rohrer et al., 2010; Whitwell et al., 2009). For presymptomatic MAPT carriers, studies have been mixed, with studies showing either no apparent gray matter deficits, or deficits in region of interest parcellations (Dopper et al., 2014; Rohrer et al., 2015). We studied a large cohort of presymptomatic and symptomatic MAPT carriers using a voxelwise approach to further refine neuroanatomical deficits and to examine relationships between gray matter and age. We studied 16 symptomatic MAPT carriers (age 55.3 ± 9.0, 10 female), 45 presymptomatic MAPT carriers (age 39.7 ± 10.5, 24 female), and 109 healthy controls (age 48.8 ± 13.3, 56 female) who had structural brain MRI scans. Symptomatic MAPT carriers included 15 with behavioral variant frontotemporal dementia (bvFTD), among which two had comorbid progressive supranuclear palsy syndrome, and one had Parkinson's disease. One carrier had an amnestic Alzheimer's-like syndrome. Voxel-based morphometry was performed on T1 images using SPM12. We created smoothed gray matter probability maps to generate voxelwise gray matter w-maps, a method of quantifying the difference between an individual carrier's expected and actual gray matter values, to further examine structural deficits (Ossenkoppele et al., 2015). Symptomatic MAPT carriers had bilateral gray matter atrophy in frontal cortex, insula, striatum with mesial temporal atrophy present in all subjects. Presymptomatic MAPT carriers showed an anatomically similar yet milder pattern of gray matter deficits, focused within bilateral hippocampus, amygdala and lateral temporal cortices. Within these regions, deficits emerged in a subset of presymptomatic MAPT carriers as early as their late thirties, while the remaining presymptomatic carriers showed normal gray matter volumes throughout the entire age span studied. Our findings suggest that early mesial temporal gray matter deficits are detectable in a subset of presymptomatic MAPT carriers, and that these same regions were atrophied in all symptomatic MAPT carriers studied. Longitudinal studies will elucidate whether these gray matter deficits represent early neurodegeneration, neurodevelopmental deficits, or both." @default.
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• W2897618879 date "2018-07-01" @default.
• W2897618879 modified "2023-10-02" @default.
• W2897618879 title "P1‐433: GRAY MATTER DEFICITS IN SYMPTOMATIC AND PRESYMPTOMATIC <i>MAPT</i> MUTATION CARRIERS" @default.
• W2897618879 doi "https://doi.org/10.1016/j.jalz.2018.06.442" @default.
• W2897618879 hasPublicationYear "2018" @default.
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