Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897622241> ?p ?o ?g. }
- W2897622241 endingPage "501" @default.
- W2897622241 startingPage "487" @default.
- W2897622241 abstract "Abstract G protein‐coupled receptors (GPCRs) constitute the largest family of cell surface receptors that mediate numerous cell signaling pathways, and are targets of more than one‐third of clinical drugs. Thanks to the advancement of novel structural biology technologies, high‐resolution structures of GPCRs in complex with their signaling transducers, including G‐protein and arrestin, have been determined. These 3D complex structures have significantly improved our understanding of the molecular mechanism of GPCR signaling and provided a structural basis for signaling‐biased drug discovery targeting GPCRs. Here we summarize structural studies of GPCR signaling complexes with G protein and arrestin using rhodopsin as a model system, and highlight the key features of GPCR conformational states in biased signaling including the sequence motifs of receptor TM6 that determine selective coupling of G proteins, and the phosphorylation codes of GPCRs for arrestin recruitment. We envision the future of GPCR structural biology not only to solve more high‐resolution complex structures but also to show stepwise GPCR signaling complex assembly and disassembly and dynamic process of GPCR signal transduction." @default.
- W2897622241 created "2018-10-26" @default.
- W2897622241 creator A5045460299 @default.
- W2897622241 creator A5052217844 @default.
- W2897622241 creator A5052644057 @default.
- W2897622241 date "2018-12-13" @default.
- W2897622241 modified "2023-10-16" @default.
- W2897622241 title "Structural biology of G protein‐coupled receptor signaling complexes" @default.
- W2897622241 cites W1603274157 @default.
- W2897622241 cites W1969497210 @default.
- W2897622241 cites W1974496652 @default.
- W2897622241 cites W1974710770 @default.
- W2897622241 cites W1977484356 @default.
- W2897622241 cites W1981956283 @default.
- W2897622241 cites W1989971979 @default.
- W2897622241 cites W2000510012 @default.
- W2897622241 cites W2040727774 @default.
- W2897622241 cites W2041566506 @default.
- W2897622241 cites W2044775506 @default.
- W2897622241 cites W2052091241 @default.
- W2897622241 cites W2053549636 @default.
- W2897622241 cites W2059551149 @default.
- W2897622241 cites W2062575219 @default.
- W2897622241 cites W2066109743 @default.
- W2897622241 cites W2077936290 @default.
- W2897622241 cites W2079523532 @default.
- W2897622241 cites W2087663632 @default.
- W2897622241 cites W2103908315 @default.
- W2897622241 cites W2108928489 @default.
- W2897622241 cites W2135587043 @default.
- W2897622241 cites W2137588110 @default.
- W2897622241 cites W2149963584 @default.
- W2897622241 cites W2153283433 @default.
- W2897622241 cites W2165775221 @default.
- W2897622241 cites W2167857702 @default.
- W2897622241 cites W2169290598 @default.
- W2897622241 cites W2475511529 @default.
- W2897622241 cites W2499343687 @default.
- W2897622241 cites W2505532605 @default.
- W2897622241 cites W2552525175 @default.
- W2897622241 cites W2552979079 @default.
- W2897622241 cites W2589588042 @default.
- W2897622241 cites W2590136671 @default.
- W2897622241 cites W2599856682 @default.
- W2897622241 cites W2605880739 @default.
- W2897622241 cites W2607506319 @default.
- W2897622241 cites W2615145336 @default.
- W2897622241 cites W2617686703 @default.
- W2897622241 cites W2617897061 @default.
- W2897622241 cites W2618233912 @default.
- W2897622241 cites W2739933313 @default.
- W2897622241 cites W2768542634 @default.
- W2897622241 cites W2788934957 @default.
- W2897622241 cites W2800175679 @default.
- W2897622241 cites W2801711247 @default.
- W2897622241 cites W2807850657 @default.
- W2897622241 cites W2808524678 @default.
- W2897622241 cites W2809171792 @default.
- W2897622241 cites W2809662941 @default.
- W2897622241 cites W2890544573 @default.
- W2897622241 cites W2890595506 @default.
- W2897622241 doi "https://doi.org/10.1002/pro.3526" @default.
- W2897622241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6371222" @default.
- W2897622241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30311978" @default.
- W2897622241 hasPublicationYear "2018" @default.
- W2897622241 type Work @default.
- W2897622241 sameAs 2897622241 @default.
- W2897622241 citedByCount "30" @default.
- W2897622241 countsByYear W28976222412019 @default.
- W2897622241 countsByYear W28976222412020 @default.
- W2897622241 countsByYear W28976222412021 @default.
- W2897622241 countsByYear W28976222412022 @default.
- W2897622241 countsByYear W28976222412023 @default.
- W2897622241 crossrefType "journal-article" @default.
- W2897622241 hasAuthorship W2897622241A5045460299 @default.
- W2897622241 hasAuthorship W2897622241A5052217844 @default.
- W2897622241 hasAuthorship W2897622241A5052644057 @default.
- W2897622241 hasBestOaLocation W28976222411 @default.
- W2897622241 hasConcept C135285700 @default.
- W2897622241 hasConcept C150555746 @default.
- W2897622241 hasConcept C170493617 @default.
- W2897622241 hasConcept C191120209 @default.
- W2897622241 hasConcept C202033177 @default.
- W2897622241 hasConcept C2777503648 @default.
- W2897622241 hasConcept C2780827179 @default.
- W2897622241 hasConcept C55493867 @default.
- W2897622241 hasConcept C60644358 @default.
- W2897622241 hasConcept C62478195 @default.
- W2897622241 hasConcept C70721500 @default.
- W2897622241 hasConcept C74187038 @default.
- W2897622241 hasConcept C80631254 @default.
- W2897622241 hasConcept C86803240 @default.
- W2897622241 hasConcept C95444343 @default.
- W2897622241 hasConceptScore W2897622241C135285700 @default.
- W2897622241 hasConceptScore W2897622241C150555746 @default.
- W2897622241 hasConceptScore W2897622241C170493617 @default.
- W2897622241 hasConceptScore W2897622241C191120209 @default.
- W2897622241 hasConceptScore W2897622241C202033177 @default.