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• W2897623616 abstract "Elephantopus scaber has been traditionally used as liver tonic. However, the protective effect of E. scaber on ethanol-induced liver damageisstillunclear.Inthisstudy,wehavecomparedtheinvivohepatoprotectiveeffectofE.scaber withPhyllanthusnirurionthe ethanol-induced liver damage in mice. The total phenolic and total flavanoid content of E. scaber ethanol extract were determined in this study. Accelerating serum biochemical profiles (including AST, ALT, ALP, triglyceride, and total bilirubin) associated with fat drop and necrotic body in the liver section were observed in the mice treated with ethanol. Low concentration of E. scaber was able to reduce serum biochemical profiles and the fat accumulation in the liver. Furthermore, high concentration of E. scaber and positive control P. niruri were able to revert the liver damage, which is comparable to the normal control. Added to this, E. scaber did not possess any oral acute toxicity on mice. These results suggest the potential effect of this extract as a hepatoprotective agent towards-ethanol induced liver damage without any oral acute toxicity effect. These activities might be contributed, or at least in part, by its high total phenolic and flavonoid contents." @default.
• W2897623616 created "2018-10-26" @default.
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• W2897623616 date "2012-01-01" @default.
• W2897623616 modified "2023-09-24" @default.
• W2897623616 title "Hepatoprotective Activity of Elephantopusscaber on Alcohol-Induced Liver Damage in Mice" @default.
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