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• W2897623639 endingPage "489" @default.
• W2897623639 startingPage "481" @default.
• W2897623639 abstract "Purpose of review Invasive fungal disease (IFD) and cytomegalovirus (CMV) infections occur frequently, either concomitantly or sequentially in immune-compromised hosts. Although there is extensive knowledge of the risk factors for these infections as single entities, the inter-relationship between opportunistic fungii and CMV has not been comprehensively explored. Recent findings Both solid organ and stem cell transplant recipients who develop CMV invasive organ disease are at an increased risk of developing IFD, particularly aspergillosis and Pneumocystis pneumonia (PCP). Moreover, CMV viremia and recipient CMV serostatus also increased the risk of both early and late-onset IFD. Treatment-related factors, such as ganciclovir-induced neutropenia and host genetic Toll-like receptor (TLR) polymorphisms are likely to be contributory. Less is known about the relationship between CMV and IFD outside transplantation, such as in patients with hematological cancers or other chronic immunosuppressive conditions. Finally, few studies report on the relationship between CMV-specific treatments or the viral/antigen kinetics and its influence on IFD management. Summary CMV infection is associated with increased risk of IFD in posttransplant recipients because of a number of overlapping and virus-specific risk factors. Better understanding of how CMV virus, its related treatment, CMV-induced immunosuppression and host genetic factors impact on IFD is warranted." @default.
• W2897623639 created "2018-10-26" @default.
• W2897623639 creator A5037683678 @default.
• W2897623639 creator A5041039527 @default.
• W2897623639 creator A5076595076 @default.
• W2897623639 date "2018-12-01" @default.
• W2897623639 modified "2023-10-18" @default.
• W2897623639 title "Invasive fungal disease and cytomegalovirus infection: is there an association?" @default.
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• W2897623639 doi "https://doi.org/10.1097/qco.0000000000000502" @default.
• W2897623639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30299361" @default.
• W2897623639 hasPublicationYear "2018" @default.
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