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- W2897624404 abstract "3-hydroxyl-3-methylglutaryl coenzyme a reductase (HMGCR) is associated with monitoring cholesterol levels. The presence of the single-nucleotide polymorphism rs3846662 introduces alternative splicing at exon 13; the exclusion of this exon leads to a reduction in total cholesterol levels. Lower cholesterol levels have been linked to a reduction in Alzheimer's disease (AD) risk. The major allele of rs3846662, which encourages the splicing of exon 13, has recently been shown to act as a preventative allele for AD, especially in women. The purpose of our research was to replicate and confirm this finding in the Cache County Study on Memory in Aging to test for association with AD status and rate of cognitive decline We will use generalized linear model and survival curves to determine an association between AD and rs3846662. ANCOVA and multiple mix model regression will be used to determine the association of rs3846662 with covariant like sex, APOE4 allele, rate of cognitive decline Using generalized linear model regressions and survival curves, we found a significant association between AD and rs3846662 (p-value = 0.049), with a stronger association in individuals that also express the APOE4 allele (p-value = 0.016). The effect of this allele on women was insignificant (p-value = 0.129) in our findings. However, we failed to detect association between rs3846662 and delayed mild cognitive impairment (MCI) conversion to AD for either of the APOE4 allelic groups (APOE4 positive p-value = 0.663; APOE4 negative p-value = 0.671) We were able to confirm that rs3846662 is associated with reduced risk for AD without sex differences using the Cache County Study on Memory in Aging." @default.
- W2897624404 created "2018-10-26" @default.
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- W2897624404 date "2018-07-01" @default.
- W2897624404 modified "2023-10-16" @default.
- W2897624404 title "P3‐100: ASSOCIATION OF RS3846662 AS A GENETIC MODIFIER FOR ALZHEIMER'S DISEASE: THE CACHE COUNTY STUDY" @default.
- W2897624404 doi "https://doi.org/10.1016/j.jalz.2018.06.1456" @default.
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