FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897624622> ?p ?o ?g. }

• W2897624622 endingPage "92" @default.
• W2897624622 startingPage "92" @default.
• W2897624622 abstract "Testicular torsion, a common urologic emergency, is primarily caused by ischemia/reperfusion (I/R) injury of the testis. Nitric oxide (NO)-derived from nitrite (NO2−) has been reported to have prominent therapeutic effects on I/R injury in the heart, liver, and brain; however, its effects on testicular I/R injury have not been evaluated. This study, therefore, investigated whether NO from NO2− is beneficial in a rat model of testicular I/R injury which eventually results in impaired spermatogenesis. Male Sprague-Dawley rats were assigned to the following seven groups: group A, sham-operated control group; Group B, I/R with no treatment; Groups C, D, and E, I/R followed by treatment with three different doses of NO2−; Group F, I/R followed by administration of NO2− and NO scavenger (2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt [C-PTIO]); and Group G, I/R followed by administration of nitrate (NO3−). NO2−, NO3−, and C-PTIO were intravenously administered. Histological examination of the testes and the western blot analysis of caspase-3 were performed. Levels of antioxidant enzymes and lipid peroxidation were measured. Germ cell apoptosis, oxidative stress, antioxidant enzymatic function, and lipid peroxidation in Group B were significantly higher than those in Group A. Group B exhibited an abnormal testicular morphology and impaired spermatogenesis. In contrast, testicular damages were attenuated in the NO2− treatment groups, which were caused by reduction in superoxide and peroxynitrite levels and an inhibition of caspase-3-dependent apoptosis. The results of this study suggest NO2− to be a promising therapeutic agent with anti-oxidant and anti-apoptotic properties in testicular I/R injury." @default.
• W2897624622 created "2018-10-26" @default.
• W2897624622 creator A5009084505 @default.
• W2897624622 creator A5032707769 @default.
• W2897624622 creator A5057408888 @default.
• W2897624622 creator A5067436574 @default.
• W2897624622 date "2019-01-01" @default.
• W2897624622 modified "2023-09-26" @default.
• W2897624622 title "Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury" @default.
• W2897624622 cites W1500167557 @default.
• W2897624622 cites W1545266136 @default.
• W2897624622 cites W1589586351 @default.
• W2897624622 cites W182778844 @default.
• W2897624622 cites W186268066 @default.
• W2897624622 cites W1964073077 @default.
• W2897624622 cites W1965740224 @default.
• W2897624622 cites W1968073601 @default.
• W2897624622 cites W1973480138 @default.
• W2897624622 cites W1993183183 @default.
• W2897624622 cites W2005466083 @default.
• W2897624622 cites W2009601307 @default.
• W2897624622 cites W2010149177 @default.
• W2897624622 cites W2014848058 @default.
• W2897624622 cites W2016646182 @default.
• W2897624622 cites W2024650410 @default.
• W2897624622 cites W2026487624 @default.
• W2897624622 cites W2030984782 @default.
• W2897624622 cites W2033357754 @default.
• W2897624622 cites W2039979152 @default.
• W2897624622 cites W2047241001 @default.
• W2897624622 cites W2051751881 @default.
• W2897624622 cites W2060208551 @default.
• W2897624622 cites W2061158829 @default.
• W2897624622 cites W2080842966 @default.
• W2897624622 cites W2094051883 @default.
• W2897624622 cites W2094949453 @default.
• W2897624622 cites W2097970837 @default.
• W2897624622 cites W2098453482 @default.
• W2897624622 cites W2099094190 @default.
• W2897624622 cites W2099649534 @default.
• W2897624622 cites W2109960090 @default.
• W2897624622 cites W2118917131 @default.
• W2897624622 cites W2125386279 @default.
• W2897624622 cites W2131450622 @default.
• W2897624622 cites W2132590504 @default.
• W2897624622 cites W2137137628 @default.
• W2897624622 cites W2146960356 @default.
• W2897624622 cites W2157777887 @default.
• W2897624622 cites W2165949229 @default.
• W2897624622 cites W2167866149 @default.
• W2897624622 cites W2169182236 @default.
• W2897624622 cites W2417071683 @default.
• W2897624622 cites W4299961382 @default.
• W2897624622 doi "https://doi.org/10.4103/aja.aja_76_18" @default.
• W2897624622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6337950" @default.
• W2897624622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30319134" @default.
• W2897624622 hasPublicationYear "2019" @default.
• W2897624622 type Work @default.
• W2897624622 sameAs 2897624622 @default.
• W2897624622 citedByCount "4" @default.
• W2897624622 countsByYear W28976246222019 @default.
• W2897624622 countsByYear W28976246222020 @default.
• W2897624622 countsByYear W28976246222021 @default.
• W2897624622 crossrefType "journal-article" @default.
• W2897624622 hasAuthorship W2897624622A5009084505 @default.
• W2897624622 hasAuthorship W2897624622A5032707769 @default.
• W2897624622 hasAuthorship W2897624622A5057408888 @default.
• W2897624622 hasAuthorship W2897624622A5067436574 @default.
• W2897624622 hasBestOaLocation W28976246221 @default.
• W2897624622 hasConcept C126322002 @default.
• W2897624622 hasConcept C134018914 @default.
• W2897624622 hasConcept C141071460 @default.
• W2897624622 hasConcept C181199279 @default.
• W2897624622 hasConcept C185592680 @default.
• W2897624622 hasConcept C2776151105 @default.
• W2897624622 hasConcept C2777622882 @default.
• W2897624622 hasConcept C2778004101 @default.
• W2897624622 hasConcept C2778784160 @default.
• W2897624622 hasConcept C2779170295 @default.
• W2897624622 hasConcept C2780114680 @default.
• W2897624622 hasConcept C2780795997 @default.
• W2897624622 hasConcept C2780829032 @default.
• W2897624622 hasConcept C519581460 @default.
• W2897624622 hasConcept C541997718 @default.
• W2897624622 hasConcept C55493867 @default.
• W2897624622 hasConcept C71924100 @default.
• W2897624622 hasConcept C98274493 @default.
• W2897624622 hasConceptScore W2897624622C126322002 @default.
• W2897624622 hasConceptScore W2897624622C134018914 @default.
• W2897624622 hasConceptScore W2897624622C141071460 @default.
• W2897624622 hasConceptScore W2897624622C181199279 @default.
• W2897624622 hasConceptScore W2897624622C185592680 @default.
• W2897624622 hasConceptScore W2897624622C2776151105 @default.
• W2897624622 hasConceptScore W2897624622C2777622882 @default.
• W2897624622 hasConceptScore W2897624622C2778004101 @default.
• W2897624622 hasConceptScore W2897624622C2778784160 @default.
• W2897624622 hasConceptScore W2897624622C2779170295 @default.
• W2897624622 hasConceptScore W2897624622C2780114680 @default.

• next