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• W2897626332 abstract "Twenty kilodalton human growth hormone (20K-GH) is the second most abundant GH isoform after the twenty-two kilodalton human growth hormone (22 K-GH) isoform. 20K-GH exhibits similar but not identical physiological activities as that of 22K-GH. The cell behaviour of 22K-GH has been extensively studied, but little or no information has been reported regarding 20K-GH. Here, we focussed on the internalization of 20K-GH. We found that the internalization of 20K-GH is rapid and occurs in a time- and dose-dependent manner. 20K-GH internalization is mediated by GHR. It appears that the internalization of 20K-GH and GHR into the cytoplasm is mediated by clathrin and/or caveolin. The current study indicates that 20K-GH can internalize into the cytoplasm and suggests that the internalized 20K-GH may exhibit different functions from those of 22K-GH." @default.
• W2897626332 created "2018-10-26" @default.
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• W2897626332 date "2019-01-01" @default.
• W2897626332 modified "2023-10-16" @default.
• W2897626332 title "Cellular internalization and trafficking of 20 KDa human growth hormone" @default.
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• W2897626332 doi "https://doi.org/10.1016/j.ygcen.2018.10.009" @default.
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