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- W2897628067 endingPage "17" @default.
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- W2897628067 abstract "Natural products are used widely for preventing intimal hyperplasia (IH), a common cardiovascular disease. Four different cells initiate and progress IH, namely, vascular smooth muscle, adventitial and endothelial cells, and circulation or bone marrow-derived cells. Vascular smooth muscle cells (VSMCs) play a critical role in initiation and development of intimal thickening and formation of neointimal hyperplasia. In this review, we describe the different originating cells involved in vascular IH and emphasize the effect of different natural products on inhibiting abnormal cellular functions, such as VSMC proliferation and migration. We further present a classification for the different natural products like phenols, flavonoids, terpenes, and alkaloids that suppress VSMC growth. Abnormal VSMC physiology involves disturbance in MAPKs, PI3K/AKT, JAK-STAT, FAK, and NF- κ B signal pathways. Most of the natural isolate studies have revealed G1/S phase of cell cycle arrest, decreased ROS production, induced cell apoptosis, restrained migration, and downregulated collagen deposition. It is necessary to screen optimal drugs from natural sources that preferentially inhibit VSMC rather than vascular endothelial cell growth to prevent early IH, restenosis following graft implantation, and atherosclerotic diseases." @default.
- W2897628067 created "2018-10-26" @default.
- W2897628067 creator A5001237555 @default.
- W2897628067 creator A5006322525 @default.
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- W2897628067 creator A5042448398 @default.
- W2897628067 creator A5068039406 @default.
- W2897628067 creator A5086417128 @default.
- W2897628067 date "2018-10-11" @default.
- W2897628067 modified "2023-10-16" @default.
- W2897628067 title "Plant-Derived Products for Treatment of Vascular Intima Hyperplasia Selectively Inhibit Vascular Smooth Muscle Cell Functions" @default.
- W2897628067 cites W1163742446 @default.
- W2897628067 cites W1491000488 @default.
- W2897628067 cites W1500925969 @default.
- W2897628067 cites W1554294005 @default.
- W2897628067 cites W1608508809 @default.
- W2897628067 cites W1820063374 @default.
- W2897628067 cites W1914809599 @default.
- W2897628067 cites W1964234749 @default.
- W2897628067 cites W1965147778 @default.
- W2897628067 cites W1965686417 @default.
- W2897628067 cites W1966294352 @default.
- W2897628067 cites W1967434220 @default.
- W2897628067 cites W1972348946 @default.
- W2897628067 cites W1973882296 @default.
- W2897628067 cites W1977878457 @default.
- W2897628067 cites W1979082387 @default.
- W2897628067 cites W1984160482 @default.
- W2897628067 cites W1986548020 @default.
- W2897628067 cites W1989359918 @default.
- W2897628067 cites W1989807089 @default.
- W2897628067 cites W1990065094 @default.
- W2897628067 cites W1992572873 @default.
- W2897628067 cites W1996917470 @default.
- W2897628067 cites W2007464448 @default.
- W2897628067 cites W2007867037 @default.
- W2897628067 cites W2009693550 @default.
- W2897628067 cites W2021467980 @default.
- W2897628067 cites W2021705436 @default.
- W2897628067 cites W2023873043 @default.
- W2897628067 cites W2025018535 @default.
- W2897628067 cites W2028835178 @default.
- W2897628067 cites W2032197504 @default.
- W2897628067 cites W2035387591 @default.
- W2897628067 cites W2038728635 @default.
- W2897628067 cites W2043117244 @default.
- W2897628067 cites W2051826326 @default.
- W2897628067 cites W2051850195 @default.
- W2897628067 cites W2052926123 @default.
- W2897628067 cites W2054336520 @default.
- W2897628067 cites W2056823205 @default.
- W2897628067 cites W2057138068 @default.
- W2897628067 cites W2059162505 @default.
- W2897628067 cites W2060320299 @default.
- W2897628067 cites W2065489192 @default.
- W2897628067 cites W2067246445 @default.
- W2897628067 cites W2069211261 @default.
- W2897628067 cites W2075490622 @default.
- W2897628067 cites W2077270246 @default.
- W2897628067 cites W2081403531 @default.
- W2897628067 cites W2084502389 @default.
- W2897628067 cites W2086070603 @default.
- W2897628067 cites W2086189875 @default.
- W2897628067 cites W2086282268 @default.
- W2897628067 cites W2088401897 @default.
- W2897628067 cites W2092757943 @default.
- W2897628067 cites W2093027926 @default.
- W2897628067 cites W2097636742 @default.
- W2897628067 cites W2102273305 @default.
- W2897628067 cites W2102791751 @default.
- W2897628067 cites W2103230017 @default.
- W2897628067 cites W2105042864 @default.
- W2897628067 cites W2110100816 @default.
- W2897628067 cites W2118837782 @default.
- W2897628067 cites W2118970688 @default.
- W2897628067 cites W2129944973 @default.
- W2897628067 cites W2130539506 @default.
- W2897628067 cites W2130595195 @default.
- W2897628067 cites W2135782858 @default.
- W2897628067 cites W2137594654 @default.
- W2897628067 cites W2142337017 @default.
- W2897628067 cites W2144703877 @default.
- W2897628067 cites W2144789534 @default.
- W2897628067 cites W2145540521 @default.
- W2897628067 cites W2145773452 @default.
- W2897628067 cites W2146038929 @default.
- W2897628067 cites W2154881794 @default.
- W2897628067 cites W2156178552 @default.
- W2897628067 cites W2158501218 @default.
- W2897628067 cites W2165751253 @default.
- W2897628067 cites W2166196759 @default.
- W2897628067 cites W2167137337 @default.
- W2897628067 cites W2167152104 @default.
- W2897628067 cites W2168938595 @default.
- W2897628067 cites W2170494766 @default.
- W2897628067 cites W2220083485 @default.
- W2897628067 cites W2233607184 @default.
- W2897628067 cites W2248600044 @default.