FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897628619> ?p ?o ?g. }

• W2897628619 abstract "We conducted this study to identify regulatory variants in cancer-related pathway genes which can predict clinical outcomes of chemotherapy in advanced NSCLC, using a comprehensive list of regulatory SNPs prioritized by RegulomeDB.A total of 509 potentially functional SNPs in cancer-related pathway genes were evaluated. The SNPs were analyzed in a discovery set (n = 198), and an independent validation set (n = 181). The associations of the SNPs with chemotherapy response and overall survival (OS) were analyzed.In the discovery set, 95 SNPs were significantly associated with clinical outcomes. Among the 95 SNPs, only rs10414193A > G in the intronic region of ARID3A, an eQTL for LKB1, was consistently associated with chemotherapy response and OS in the validation set. In combined analysis, the rs10414193A > G was significantly associated with worse response to chemotherapy (adjusted odds ratio = 0.63, 95% CI = 0.47-0.85, P = 0.002), and with worse OS (adjusted hazard ratio = 1.25, 95% CI = 1.08-1.45, P = 0.004). Luciferase assay showed a significantly higher LKB1 promoter activity associated with rs10414193G allele compared with rs10414193A allele (P = 0.0009).Our results suggest that rs10414193A > G may be useful for the prediction of clinical outcomes of chemotherapy in advanced NSCLC." @default.
• W2897628619 created "2018-10-26" @default.
• W2897628619 creator A5006227181 @default.
• W2897628619 creator A5008078972 @default.
• W2897628619 creator A5012086701 @default.
• W2897628619 creator A5012863258 @default.
• W2897628619 creator A5030593586 @default.
• W2897628619 creator A5032172727 @default.
• W2897628619 creator A5037365628 @default.
• W2897628619 creator A5038460242 @default.
• W2897628619 creator A5039670861 @default.
• W2897628619 creator A5043635507 @default.
• W2897628619 creator A5047290635 @default.
• W2897628619 creator A5048502103 @default.
• W2897628619 creator A5063823690 @default.
• W2897628619 creator A5069522652 @default.
• W2897628619 creator A5070267071 @default.
• W2897628619 creator A5089261394 @default.
• W2897628619 date "2018-12-01" @default.
• W2897628619 modified "2023-10-16" @default.
• W2897628619 title "An expression quantitative trait locus variant for LKB1 gene predicts the clinical outcomes of chemotherapy in patients with non-small cell lung cancer" @default.
• W2897628619 cites W1975646933 @default.
• W2897628619 cites W1986232151 @default.
• W2897628619 cites W2037139573 @default.
• W2897628619 cites W2044874695 @default.
• W2897628619 cites W2065260669 @default.
• W2897628619 cites W2083828731 @default.
• W2897628619 cites W2084649602 @default.
• W2897628619 cites W2098930497 @default.
• W2897628619 cites W2099530756 @default.
• W2897628619 cites W2102891343 @default.
• W2897628619 cites W2117446594 @default.
• W2897628619 cites W2126452795 @default.
• W2897628619 cites W2141820415 @default.
• W2897628619 cites W2152751895 @default.
• W2897628619 cites W2161528698 @default.
• W2897628619 cites W2165640222 @default.
• W2897628619 cites W2166084034 @default.
• W2897628619 cites W2170034446 @default.
• W2897628619 cites W2187181884 @default.
• W2897628619 cites W2259938310 @default.
• W2897628619 cites W2264427141 @default.
• W2897628619 cites W2408314639 @default.
• W2897628619 cites W2566863750 @default.
• W2897628619 cites W2735619682 @default.
• W2897628619 cites W3145077989 @default.
• W2897628619 doi "https://doi.org/10.1016/j.cancergen.2018.10.002" @default.
• W2897628619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30553476" @default.
• W2897628619 hasPublicationYear "2018" @default.
• W2897628619 type Work @default.
• W2897628619 sameAs 2897628619 @default.
• W2897628619 citedByCount "3" @default.
• W2897628619 countsByYear W28976286192019 @default.
• W2897628619 countsByYear W28976286192020 @default.
• W2897628619 crossrefType "journal-article" @default.
• W2897628619 hasAuthorship W2897628619A5006227181 @default.
• W2897628619 hasAuthorship W2897628619A5008078972 @default.
• W2897628619 hasAuthorship W2897628619A5012086701 @default.
• W2897628619 hasAuthorship W2897628619A5012863258 @default.
• W2897628619 hasAuthorship W2897628619A5030593586 @default.
• W2897628619 hasAuthorship W2897628619A5032172727 @default.
• W2897628619 hasAuthorship W2897628619A5037365628 @default.
• W2897628619 hasAuthorship W2897628619A5038460242 @default.
• W2897628619 hasAuthorship W2897628619A5039670861 @default.
• W2897628619 hasAuthorship W2897628619A5043635507 @default.
• W2897628619 hasAuthorship W2897628619A5047290635 @default.
• W2897628619 hasAuthorship W2897628619A5048502103 @default.
• W2897628619 hasAuthorship W2897628619A5063823690 @default.
• W2897628619 hasAuthorship W2897628619A5069522652 @default.
• W2897628619 hasAuthorship W2897628619A5070267071 @default.
• W2897628619 hasAuthorship W2897628619A5089261394 @default.
• W2897628619 hasConcept C104317684 @default.
• W2897628619 hasConcept C121608353 @default.
• W2897628619 hasConcept C126322002 @default.
• W2897628619 hasConcept C135763542 @default.
• W2897628619 hasConcept C143998085 @default.
• W2897628619 hasConcept C153209595 @default.
• W2897628619 hasConcept C156957248 @default.
• W2897628619 hasConcept C168393362 @default.
• W2897628619 hasConcept C180754005 @default.
• W2897628619 hasConcept C207103383 @default.
• W2897628619 hasConcept C2776256026 @default.
• W2897628619 hasConcept C2776694085 @default.
• W2897628619 hasConcept C44249647 @default.
• W2897628619 hasConcept C50382708 @default.
• W2897628619 hasConcept C54355233 @default.
• W2897628619 hasConcept C60644358 @default.
• W2897628619 hasConcept C71924100 @default.
• W2897628619 hasConcept C84597430 @default.
• W2897628619 hasConcept C86803240 @default.
• W2897628619 hasConceptScore W2897628619C104317684 @default.
• W2897628619 hasConceptScore W2897628619C121608353 @default.
• W2897628619 hasConceptScore W2897628619C126322002 @default.
• W2897628619 hasConceptScore W2897628619C135763542 @default.
• W2897628619 hasConceptScore W2897628619C143998085 @default.
• W2897628619 hasConceptScore W2897628619C153209595 @default.
• W2897628619 hasConceptScore W2897628619C156957248 @default.
• W2897628619 hasConceptScore W2897628619C168393362 @default.
• W2897628619 hasConceptScore W2897628619C180754005 @default.
• W2897628619 hasConceptScore W2897628619C207103383 @default.

• next