FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897631685> ?p ?o ?g. }

• W2897631685 abstract "Treatment options for Ankylosing Spondylitis (AS) are still limited. The T helper cell 17 (Th17) pathway has emerged as a major driver of disease pathogenesis and a good treatment target. Janus kinases (JAK) are key transducers of cytokine signals in Th17 cells and therefore promising targets for the treatment of AS. Here we investigate the therapeutic potential of four different JAK inhibitors on cells derived from AS patients and healthy controls, cultured in-vitro under Th17-promoting conditions. Levels of IL-17A, IL-17F, IL-22, GM-CSF and IFNγ were assessed by ELISA and inhibitory effects were investigated with Phosphoflow. JAK1/2/3 and TYK2 were silenced in CD4+ T cells with siRNA and effects analyzed by ELISA (IL-17A, IL-17F and IL-22), Western Blot, qPCR and Phosphoflow. In-vitro inhibition of CD4+ T lymphocyte production of multiple Th17 cytokines (IL-17A, IL-17F and IL-22) was achieved with JAK inhibitors of differing specificity, as well as by silencing of JAK1-3 and Tyk2, without impacting on cell viability or proliferation. Our preclinical data suggest JAK inhibitors as promising candidates for therapeutic trials in AS, since they can inhibit multiple Th17 cytokines simultaneously. Improved targeting of TYK2 or other JAK isoforms may confer tailored effects on Th17 responses in AS." @default.
• W2897631685 created "2018-10-26" @default.
• W2897631685 creator A5005329243 @default.
• W2897631685 creator A5012781890 @default.
• W2897631685 creator A5018347126 @default.
• W2897631685 creator A5029195022 @default.
• W2897631685 creator A5031641654 @default.
• W2897631685 creator A5041375999 @default.
• W2897631685 creator A5042652724 @default.
• W2897631685 creator A5053248537 @default.
• W2897631685 creator A5059194884 @default.
• W2897631685 creator A5069267567 @default.
• W2897631685 date "2018-10-23" @default.
• W2897631685 modified "2023-10-03" @default.
• W2897631685 title "Inhibiting ex-vivo Th17 responses in Ankylosing Spondylitis by targeting Janus kinases" @default.
• W2897631685 cites W1537063289 @default.
• W2897631685 cites W1847326477 @default.
• W2897631685 cites W1878264508 @default.
• W2897631685 cites W1969979508 @default.
• W2897631685 cites W1976173775 @default.
• W2897631685 cites W1982542795 @default.
• W2897631685 cites W1988212011 @default.
• W2897631685 cites W1990305566 @default.
• W2897631685 cites W1994107743 @default.
• W2897631685 cites W2026853694 @default.
• W2897631685 cites W2061217789 @default.
• W2897631685 cites W2081388746 @default.
• W2897631685 cites W2084388036 @default.
• W2897631685 cites W2095522674 @default.
• W2897631685 cites W2100772783 @default.
• W2897631685 cites W2107909189 @default.
• W2897631685 cites W2109172918 @default.
• W2897631685 cites W2117926449 @default.
• W2897631685 cites W2118434625 @default.
• W2897631685 cites W2121219094 @default.
• W2897631685 cites W2123414080 @default.
• W2897631685 cites W2127378843 @default.
• W2897631685 cites W2128551987 @default.
• W2897631685 cites W2134009713 @default.
• W2897631685 cites W2143556657 @default.
• W2897631685 cites W2151734278 @default.
• W2897631685 cites W2163184895 @default.
• W2897631685 cites W2164858045 @default.
• W2897631685 cites W2171202452 @default.
• W2897631685 cites W2220479222 @default.
• W2897631685 cites W2257779930 @default.
• W2897631685 cites W2278932593 @default.
• W2897631685 cites W2341271443 @default.
• W2897631685 cites W2465223145 @default.
• W2897631685 cites W2547876355 @default.
• W2897631685 cites W2554626374 @default.
• W2897631685 cites W2586850343 @default.
• W2897631685 cites W2593565645 @default.
• W2897631685 cites W2767945940 @default.
• W2897631685 cites W4211170289 @default.
• W2897631685 doi "https://doi.org/10.1038/s41598-018-34026-1" @default.
• W2897631685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199284" @default.
• W2897631685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353145" @default.
• W2897631685 hasPublicationYear "2018" @default.
• W2897631685 type Work @default.
• W2897631685 sameAs 2897631685 @default.
• W2897631685 citedByCount "24" @default.
• W2897631685 countsByYear W28976316852019 @default.
• W2897631685 countsByYear W28976316852020 @default.
• W2897631685 countsByYear W28976316852021 @default.
• W2897631685 countsByYear W28976316852022 @default.
• W2897631685 countsByYear W28976316852023 @default.
• W2897631685 crossrefType "journal-article" @default.
• W2897631685 hasAuthorship W2897631685A5005329243 @default.
• W2897631685 hasAuthorship W2897631685A5012781890 @default.
• W2897631685 hasAuthorship W2897631685A5018347126 @default.
• W2897631685 hasAuthorship W2897631685A5029195022 @default.
• W2897631685 hasAuthorship W2897631685A5031641654 @default.
• W2897631685 hasAuthorship W2897631685A5041375999 @default.
• W2897631685 hasAuthorship W2897631685A5042652724 @default.
• W2897631685 hasAuthorship W2897631685A5053248537 @default.
• W2897631685 hasAuthorship W2897631685A5059194884 @default.
• W2897631685 hasAuthorship W2897631685A5069267567 @default.
• W2897631685 hasBestOaLocation W28976316851 @default.
• W2897631685 hasConcept C104317684 @default.
• W2897631685 hasConcept C112392421 @default.
• W2897631685 hasConcept C119056186 @default.
• W2897631685 hasConcept C126322002 @default.
• W2897631685 hasConcept C130523297 @default.
• W2897631685 hasConcept C154390347 @default.
• W2897631685 hasConcept C157333092 @default.
• W2897631685 hasConcept C170493617 @default.
• W2897631685 hasConcept C180361614 @default.
• W2897631685 hasConcept C184235292 @default.
• W2897631685 hasConcept C203014093 @default.
• W2897631685 hasConcept C2775960820 @default.
• W2897631685 hasConcept C2777402515 @default.
• W2897631685 hasConcept C2778690821 @default.
• W2897631685 hasConcept C2778923194 @default.
• W2897631685 hasConcept C42362537 @default.
• W2897631685 hasConcept C47348012 @default.
• W2897631685 hasConcept C502942594 @default.
• W2897631685 hasConcept C55493867 @default.
• W2897631685 hasConcept C62478195 @default.
• W2897631685 hasConcept C71924100 @default.

• next