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• W2897634457 abstract "Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key signaling networks that result in excessive inflammation and collateral tissue damage. In particular, zinc impacts macrophage function, a critical front-line cell in host defense, in addition to other immune cells. Deficits in zinc adversely impact macrophage function resulting in dysregulation of phagocytosis, intracellular killing, and cytokine production. An additional work in this field has revealed a vital role for several zinc transporter proteins that are required for proper bioredistribution of zinc within mononuclear cells to achieve an optimal immune response against invading microorganisms. In this review, we will discuss the most recent developments regarding zinc’s role in innate immunity and protection against pathogen invasion." @default.
• W2897634457 created "2018-10-26" @default.
• W2897634457 creator A5015986486 @default.
• W2897634457 creator A5036666949 @default.
• W2897634457 date "2018-10-17" @default.
• W2897634457 modified "2023-10-13" @default.
• W2897634457 title "Essential Role of Zinc and Zinc Transporters in Myeloid Cell Function and Host Defense against Infection" @default.
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• W2897634457 doi "https://doi.org/10.1155/2018/4315140" @default.
• W2897634457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6207864" @default.
• W2897634457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30417019" @default.
• W2897634457 hasPublicationYear "2018" @default.
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