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• W2897635230 abstract "Summary The Drosophila neoplastic tumor suppressor gene (nTSG) mutant tumors have successfully modeled many aspects of human tumor progression. However, the fly nTSG mutant tumors progress rapidly over days. This is in contrast with most human tumors which develop slowly, harbor heterogeneous cell populations for selection and undergo an evolution-like process. Whether the fast-growing fly nTSG mutant tumors have capacity for evolution remains unclear. Through quantitative analysis of the scrib mutant tumor growth, we found that the scrib mutant tumors evolve to display different growth rates and cell cycle profiles over time. Multiple growth-regulatory signaling pathways show quantitative differences in early versus late scrib mutant tumors. These data suggest that the scrib mutant tumors undergo a transition from a growth arrest state to a proliferative state. Through longitudinal single cell RNA (scRNA) data analysis we found that the scrib mutant tumors harbor heterogeneous cell populations likely of distinct proliferative states, which are available for potential selection. This study raises the possibility of studying tumor evolution in a genetically accessible and fast-growing invertebrate tumor model." @default.
• W2897635230 created "2018-10-26" @default.
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• W2897635230 date "2018-10-23" @default.
• W2897635230 modified "2023-10-16" @default.
• W2897635230 title "Drosophila scribble mutant tumors undergo a transition from a growth arrest state to a proliferative state over time" @default.
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• W2897635230 doi "https://doi.org/10.1101/450486" @default.
• W2897635230 hasPublicationYear "2018" @default.
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