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- W2897637459 abstract "Establishment of precise 3-dimensional tissue structure is vital for organ function. In the visual system, optic fissure and stalk morphogenesis is a critical, yet poorly understood process, disruptions of which can lead to coloboma, a birth defect causing visual impairment. Here, we use 4-dimensional imaging, cell tracking, and molecular genetics in zebrafish to define cell movements underlying normal optic fissure and stalk formation. We determine how these events are disrupted in a coloboma model in which the Hedgehog receptor ptch2 is lost, resulting in overactive Hh signaling. In the ptch2 mutant, cells exhibit defective motile behaviors and morphology. Cells that should contribute to the fissure do not arrive at their correct position, and instead contribute to an ectopically large optic stalk. Our results suggest that overactive Hh signaling, through overexpression of downstream transcriptional targets, impairs cell motility underlying optic fissure and stalk formation, via non-cell autonomous and cell-autonomous mechanisms. More broadly, our cell motility and morphology analyses provide a new framework to study other coloboma-causing mutations disrupting optic fissure or stalk formation." @default.
- W2897637459 created "2018-10-26" @default.
- W2897637459 creator A5005150676 @default.
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- W2897637459 date "2018-01-01" @default.
- W2897637459 modified "2023-10-01" @default.
- W2897637459 title "Hedgehog signaling regulates cell motility and optic fissure and stalk formation during vertebrate eye morphogenesis" @default.
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- W2897637459 cites W1965178710 @default.
- W2897637459 cites W1969381388 @default.
- W2897637459 cites W1971993655 @default.
- W2897637459 cites W1978751527 @default.
- W2897637459 cites W1979902384 @default.
- W2897637459 cites W1986492163 @default.
- W2897637459 cites W1989189463 @default.
- W2897637459 cites W1989239695 @default.
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- W2897637459 cites W1991252317 @default.
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- W2897637459 cites W2010399890 @default.
- W2897637459 cites W2011792503 @default.
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- W2897637459 cites W2021972893 @default.
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- W2897637459 cites W2027512063 @default.
- W2897637459 cites W2034054538 @default.
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- W2897637459 doi "https://doi.org/10.1242/dev.165068" @default.
- W2897637459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6262791" @default.
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