Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897638324> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2897638324 endingPage "331" @default.
- W2897638324 startingPage "326" @default.
- W2897638324 abstract "Telomeres are the ends of the linear chromosomes of eukaryotes and consist of tandem GT-rich repeats in telomere sequence i.e. 500-3000 repeats of 5'-TTAGGG-3' in human somatic cells, which are shortened gradually with age. The G-rich overhang of telomere sequence can adopt different intramolecular fold-backs and tetra-stranded DNA structures, in vitro, which inhibit telomerase activity. In this report, DNA binding agents to telomere sequence were studied novel therapeutic possibility to destabilize telomeric DNA sequences. Oligonucleotides containing the guanine repeats in human telomere sequence were synthesized and used for screening potential antitumor drugs. Telomeric DNA sequence was characterized using spectral measurements and CD spectroscopy. CD spectrum indicated that the double-stranded telomeric DNA is in a right-handed conformation. Polyacrylamide gel electrophoresis was performed for binding behaviors of antitumor compounds with telomeric DNA sequence. Drugs interacted with DNA sequence caused changes in the electrophoretic mobility and band intensity of the gels. Depending on the binding mode of the anticancer drugs, telomeric DNA sequence was differently recognized and the efficiency of cleavage of DNA varies in the bleomycin-treated samples under different conditions. DNA cleavage occurred at about 1% by the increments of 1 micromM bleomycin-Fe(III). These results imply that the stability of human telomere sequence is important in conjunction with the cancer treatment and aging process." @default.
- W2897638324 created "2018-10-26" @default.
- W2897638324 creator A5009756874 @default.
- W2897638324 creator A5014332786 @default.
- W2897638324 creator A5031410215 @default.
- W2897638324 creator A5038333595 @default.
- W2897638324 creator A5042106806 @default.
- W2897638324 creator A5046999934 @default.
- W2897638324 creator A5069641581 @default.
- W2897638324 creator A5090021812 @default.
- W2897638324 date "2002-11-01" @default.
- W2897638324 modified "2023-10-16" @default.
- W2897638324 title "Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence" @default.
- W2897638324 cites W2072626632 @default.
- W2897638324 cites W2745920970 @default.
- W2897638324 doi "https://doi.org/10.1038/emm.2002.46" @default.
- W2897638324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12526095" @default.
- W2897638324 hasPublicationYear "2002" @default.
- W2897638324 type Work @default.
- W2897638324 sameAs 2897638324 @default.
- W2897638324 citedByCount "6" @default.
- W2897638324 countsByYear W28976383242014 @default.
- W2897638324 countsByYear W28976383242017 @default.
- W2897638324 crossrefType "journal-article" @default.
- W2897638324 hasAuthorship W2897638324A5009756874 @default.
- W2897638324 hasAuthorship W2897638324A5014332786 @default.
- W2897638324 hasAuthorship W2897638324A5031410215 @default.
- W2897638324 hasAuthorship W2897638324A5038333595 @default.
- W2897638324 hasAuthorship W2897638324A5042106806 @default.
- W2897638324 hasAuthorship W2897638324A5046999934 @default.
- W2897638324 hasAuthorship W2897638324A5069641581 @default.
- W2897638324 hasAuthorship W2897638324A5090021812 @default.
- W2897638324 hasBestOaLocation W28976383241 @default.
- W2897638324 hasConcept C104317684 @default.
- W2897638324 hasConcept C129312508 @default.
- W2897638324 hasConcept C134305767 @default.
- W2897638324 hasConcept C153911025 @default.
- W2897638324 hasConcept C177336024 @default.
- W2897638324 hasConcept C2778301229 @default.
- W2897638324 hasConcept C512185932 @default.
- W2897638324 hasConcept C54355233 @default.
- W2897638324 hasConcept C552990157 @default.
- W2897638324 hasConcept C86803240 @default.
- W2897638324 hasConcept C94581717 @default.
- W2897638324 hasConceptScore W2897638324C104317684 @default.
- W2897638324 hasConceptScore W2897638324C129312508 @default.
- W2897638324 hasConceptScore W2897638324C134305767 @default.
- W2897638324 hasConceptScore W2897638324C153911025 @default.
- W2897638324 hasConceptScore W2897638324C177336024 @default.
- W2897638324 hasConceptScore W2897638324C2778301229 @default.
- W2897638324 hasConceptScore W2897638324C512185932 @default.
- W2897638324 hasConceptScore W2897638324C54355233 @default.
- W2897638324 hasConceptScore W2897638324C552990157 @default.
- W2897638324 hasConceptScore W2897638324C86803240 @default.
- W2897638324 hasConceptScore W2897638324C94581717 @default.
- W2897638324 hasIssue "5" @default.
- W2897638324 hasLocation W28976383241 @default.
- W2897638324 hasLocation W28976383242 @default.
- W2897638324 hasOpenAccess W2897638324 @default.
- W2897638324 hasPrimaryLocation W28976383241 @default.
- W2897638324 hasRelatedWork W1997187052 @default.
- W2897638324 hasRelatedWork W2076335297 @default.
- W2897638324 hasRelatedWork W2087568613 @default.
- W2897638324 hasRelatedWork W2098695343 @default.
- W2897638324 hasRelatedWork W2358441296 @default.
- W2897638324 hasRelatedWork W2595940044 @default.
- W2897638324 hasRelatedWork W2780663388 @default.
- W2897638324 hasRelatedWork W2808345459 @default.
- W2897638324 hasRelatedWork W2897638324 @default.
- W2897638324 hasRelatedWork W3092533156 @default.
- W2897638324 hasVolume "34" @default.
- W2897638324 isParatext "false" @default.
- W2897638324 isRetracted "false" @default.
- W2897638324 magId "2897638324" @default.
- W2897638324 workType "article" @default.