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- W2897640446 abstract "Abstract The bloodstream form of the parasite Trypanosoma brucei obtains iron from its mammalian host by receptor-mediated endocytosis of host transferrin through its own unique transferrin receptor ( Tb TfR). Expression of Tb TfR rapidly increases upon iron starvation by post-transcriptional regulation through a currently undefined mechanism that is distinct from the mammalian iron response system. We have created reporter cell lines by fusing the Tb TfR 3′UTR or a control Aldolase 3’UTR to reporter genes encoding GFP or firefly Luciferase, and inserted the fusions into a bloodstream form cell line at a tagged ribosomal RNA locus. Fusion of the Tb TfR 3’UTR is sufficient to significantly repress the expression of the reporter proteins under normal growth conditions. Under iron starvation conditions we observed upregulation of the Tb TfR 3’UTR fusions only, with a magnitude and timing consistent with that reported for upregulation of the Tb TfR. We conclude that the dynamic regulation of the T. brucei transferrin receptor in response to iron starvation is mediated via its 3’UTR, and that the effect is independent of genomic location." @default.
- W2897640446 created "2018-10-26" @default.
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- W2897640446 date "2018-10-12" @default.
- W2897640446 modified "2023-09-26" @default.
- W2897640446 title "Dynamic regulation of the Trypanosoma brucei transferrin receptor in response to iron starvation is mediated via the 3’UTR" @default.
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- W2897640446 doi "https://doi.org/10.1101/441931" @default.
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