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- W2897645746 abstract "Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and microglia directly communicate with one another and differentially modulate each other's functions. Importantly, microglia-mediated phagocytosis and inflammation are suppressed by infiltrating macrophages. In the context of spinal cord injury (SCI), preventing such communication increases microglial activation and worsens functional recovery. We suggest that macrophages entering the CNS provide a regulatory mechanism that controls acute and long-term microglia-mediated inflammation, which may drive damage in a variety of CNS conditions." @default.
- W2897645746 created "2018-10-26" @default.
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- W2897645746 date "2018-10-17" @default.
- W2897645746 modified "2023-10-15" @default.
- W2897645746 title "Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury" @default.
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- W2897645746 doi "https://doi.org/10.1371/journal.pbio.2005264" @default.
- W2897645746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205650" @default.
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