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- W2897650757 abstract "Cannabis sativa is a medicinal herb with a diverse range of chemotypes that can exert both anxiolytic and anxiogenic effects on humans. Medical cannabis patients receiving organically grown cannabis from a single source were surveyed about the effectiveness of cannabis for treating anxiety. Patients rated cannabis as highly effective overall for treating anxiety with an average score of 8.03 on a Likert scale of 0 to 10 (0=not effective,10=extremely effective). Patients also identified which strains they found the most or least effective for relieving their symptoms of anxiety. To find correlations between anxiolytic activity and chemotype, the top four strains voted most and least effective were analyzed by HPLC-MS/MS to quantify cannabinoids and GC-MS to quantify terpenes. Tetrahydrocannabinol and trans-nerolidol have statistically significant correlations with increased anxiolytic activity. Guiaol, eucalyptol, γ-terpinene, α-phellandrene, 3-carene and sabinene hydrate all have significant correlations with decreased anxiolytic activity. Further studies are needed to better elucidate the entourage effects that contribute to the anxiolytic properties of cannabis varieties." @default.
- W2897650757 created "2018-10-26" @default.
- W2897650757 creator A5040918695 @default.
- W2897650757 creator A5073393769 @default.
- W2897650757 creator A5082688978 @default.
- W2897650757 date "2018-10-22" @default.
- W2897650757 modified "2023-10-09" @default.
- W2897650757 title "Cannabis and the Anxiety of Fragmentation—A Systems Approach for Finding an Anxiolytic Cannabis Chemotype" @default.
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- W2897650757 doi "https://doi.org/10.3389/fnins.2018.00730" @default.
- W2897650757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6204402" @default.
- W2897650757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30405331" @default.
- W2897650757 hasPublicationYear "2018" @default.
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