FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897655579> ?p ?o ?g. }

• W2897655579 endingPage "674" @default.
• W2897655579 startingPage "674" @default.
• W2897655579 abstract "This article has been corrected. The original version (PDF) is appended to this article as a Supplement. Background: The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT), including a case of HIV cure, are not fully understood. Objective: To investigate the mechanism of HIV-1 eradication associated with allo-HSCT. Design: Nested case series within the IciStem observational cohort. Setting: Multicenter European study. Participants: 6 HIV-infected, antiretroviral-treated participants who survived more than 2 years after allo-HSCT with CCR5 wild-type donor cells. Measurements: HIV DNA analysis, HIV RNA analysis, and quantitative viral outgrowth assay were performed in blood, and HIV DNA was also measured in lymph nodes, ilea, bone marrow, and cerebrospinal fluid. A humanized mouse model was used for in vivo detection of the replication-competent blood cell reservoir. HIV-specific antibodies were measured in plasma. Results: Analysis of the viral reservoir showed that 5 of 6 participants had full donor chimera in T cells within the first year after transplant, undetectable proviral HIV DNA in blood and tissue, and undetectable replication-competent virus (<0.006 infectious unit per million cells). The only participant with detectable virus received cord blood stem cells with an antithymocyte globulin–containing conditioning regimen, did not develop graft-versus-host disease, and had delayed complete standard chimerism in T cells (18 months) with mixed ultrasensitive chimera. Adoptive transfer of peripheral CD4+ T cells to immunosuppressed mice resulted in no viral rebound. HIV antibody levels decreased over time, with 1 case of seroreversion. Limitation: Few participants. Conclusion: Allo-HSCT resulted in a profound long-term reduction in the HIV reservoir. Such factors as stem cell source, conditioning, and a possible “graft-versus-HIV-reservoir” effect may have contributed. Understanding the mechanisms involved in HIV eradication after allo-HSCT can enable design of new curative strategies. Primary Funding Source: The Foundation for AIDS Research (amfAR)." @default.
• W2897655579 created "2018-10-26" @default.
• W2897655579 creator A5002497082 @default.
• W2897655579 creator A5002845944 @default.
• W2897655579 creator A5009164884 @default.
• W2897655579 creator A5024965105 @default.
• W2897655579 creator A5028130303 @default.
• W2897655579 creator A5034694882 @default.
• W2897655579 creator A5041888795 @default.
• W2897655579 creator A5043991937 @default.
• W2897655579 creator A5049825116 @default.
• W2897655579 creator A5058930906 @default.
• W2897655579 creator A5061338963 @default.
• W2897655579 creator A5071587401 @default.
• W2897655579 creator A5076259435 @default.
• W2897655579 creator A5080704945 @default.
• W2897655579 creator A5081108638 @default.
• W2897655579 creator A5087835035 @default.
• W2897655579 date "2018-10-16" @default.
• W2897655579 modified "2023-10-18" @default.
• W2897655579 title "Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant" @default.
• W2897655579 cites W1497870368 @default.
• W2897655579 cites W1965818140 @default.
• W2897655579 cites W1969247017 @default.
• W2897655579 cites W1971791226 @default.
• W2897655579 cites W2017843172 @default.
• W2897655579 cites W2035167717 @default.
• W2897655579 cites W2035813371 @default.
• W2897655579 cites W2041380049 @default.
• W2897655579 cites W2047300635 @default.
• W2897655579 cites W2057516022 @default.
• W2897655579 cites W2059249274 @default.
• W2897655579 cites W2065379504 @default.
• W2897655579 cites W2105833356 @default.
• W2897655579 cites W2114865574 @default.
• W2897655579 cites W2124058652 @default.
• W2897655579 cites W2124444681 @default.
• W2897655579 cites W2126334008 @default.
• W2897655579 cites W2157096116 @default.
• W2897655579 cites W2215502044 @default.
• W2897655579 cites W2320298534 @default.
• W2897655579 cites W2346035223 @default.
• W2897655579 cites W2466398959 @default.
• W2897655579 cites W2599293555 @default.
• W2897655579 cites W2606667192 @default.
• W2897655579 cites W2607272905 @default.
• W2897655579 cites W2622063078 @default.
• W2897655579 doi "https://doi.org/10.7326/m18-0759" @default.
• W2897655579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326031" @default.
• W2897655579 hasPublicationYear "2018" @default.
• W2897655579 type Work @default.
• W2897655579 sameAs 2897655579 @default.
• W2897655579 citedByCount "49" @default.
• W2897655579 countsByYear W28976555792018 @default.
• W2897655579 countsByYear W28976555792019 @default.
• W2897655579 countsByYear W28976555792020 @default.
• W2897655579 countsByYear W28976555792021 @default.
• W2897655579 countsByYear W28976555792022 @default.
• W2897655579 countsByYear W28976555792023 @default.
• W2897655579 crossrefType "journal-article" @default.
• W2897655579 hasAuthorship W2897655579A5002497082 @default.
• W2897655579 hasAuthorship W2897655579A5002845944 @default.
• W2897655579 hasAuthorship W2897655579A5009164884 @default.
• W2897655579 hasAuthorship W2897655579A5024965105 @default.
• W2897655579 hasAuthorship W2897655579A5028130303 @default.
• W2897655579 hasAuthorship W2897655579A5034694882 @default.
• W2897655579 hasAuthorship W2897655579A5041888795 @default.
• W2897655579 hasAuthorship W2897655579A5043991937 @default.
• W2897655579 hasAuthorship W2897655579A5049825116 @default.
• W2897655579 hasAuthorship W2897655579A5058930906 @default.
• W2897655579 hasAuthorship W2897655579A5061338963 @default.
• W2897655579 hasAuthorship W2897655579A5071587401 @default.
• W2897655579 hasAuthorship W2897655579A5076259435 @default.
• W2897655579 hasAuthorship W2897655579A5080704945 @default.
• W2897655579 hasAuthorship W2897655579A5081108638 @default.
• W2897655579 hasAuthorship W2897655579A5087835035 @default.
• W2897655579 hasConcept C109159458 @default.
• W2897655579 hasConcept C126322002 @default.
• W2897655579 hasConcept C142462285 @default.
• W2897655579 hasConcept C159047783 @default.
• W2897655579 hasConcept C159654299 @default.
• W2897655579 hasConcept C203014093 @default.
• W2897655579 hasConcept C2522874641 @default.
• W2897655579 hasConcept C2777408962 @default.
• W2897655579 hasConcept C2780007613 @default.
• W2897655579 hasConcept C28328180 @default.
• W2897655579 hasConcept C2911091166 @default.
• W2897655579 hasConcept C54355233 @default.
• W2897655579 hasConcept C71924100 @default.
• W2897655579 hasConcept C86803240 @default.
• W2897655579 hasConceptScore W2897655579C109159458 @default.
• W2897655579 hasConceptScore W2897655579C126322002 @default.
• W2897655579 hasConceptScore W2897655579C142462285 @default.
• W2897655579 hasConceptScore W2897655579C159047783 @default.
• W2897655579 hasConceptScore W2897655579C159654299 @default.
• W2897655579 hasConceptScore W2897655579C203014093 @default.
• W2897655579 hasConceptScore W2897655579C2522874641 @default.
• W2897655579 hasConceptScore W2897655579C2777408962 @default.

• next