Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897655932> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2897655932 abstract "The amyloid plaques and neurofibrillary tangles (NFTs) are the two major hallmarks of Alzheimer's disease (AD). The histopathological studies hint distinct spreading and progression of amyloidosis and NFTs across AD stage. Given the divergent spatial patterns of the hallmarks, the association between the two abnormal protein aggregates in different brain regions is elusive. Here, we reveal the association between amyloidosis and NFTs in cognitively normal (CN), mild cognitive impairment (MCI), and AD individuals with positron emission tomography (PET). The emergence of novel PET tracers of [18F]AZD4694 for amyloidosis and [18F]MK6240 for NFTs allows precise investigation of each pathological progression in temporal and spatial in vivo. Here, we hypothesize that association between the two hallmarks spreads from posterior to anterior regions following the disease progression. A total of 16 CN, 11 MCI, and 11 AD patients was used. Each subject underwent PET [18F]AZD4694 and [18F]MK6240 acquisitions. [18F]AZD4694 image was processed from 40 minutes post-injection for 30 minutes. [18F]MK6240 image was processed from 90 minutes post-injection for 20 minutes. All images were registered to individual MRI with lsq6. Then, they are transformed into ADNI template using lsq12 with nonlinear transformations. The SUVR parametric map was generated using cerebellar grey matter as a reference region for both images. For statistical analysis, we performed voxel-wise analysis to show the association between amyloidosis and NFTs following the model in each group using VoxelStats. [18F]MK6240 SUVR ∼ [18F]AZD4694 SUVR + age + gender + APOE + education. The unique association between amyloidosis and NFTs was present in entorhinal cortex and PCC in CN; precuneus, PCC, and parahippocampal gyrus in MCI; ACC, entorhinal cortex, parahippocampal gyrus, and orbitofrontal cortex in AD. All groups showed the association in lateral temporal and middle frontal gyrus." @default.
- W2897655932 created "2018-10-26" @default.
- W2897655932 creator A5004968642 @default.
- W2897655932 creator A5006091170 @default.
- W2897655932 creator A5008077492 @default.
- W2897655932 creator A5009612708 @default.
- W2897655932 creator A5020509082 @default.
- W2897655932 creator A5026681917 @default.
- W2897655932 creator A5034862340 @default.
- W2897655932 creator A5036473548 @default.
- W2897655932 creator A5043890316 @default.
- W2897655932 creator A5048432926 @default.
- W2897655932 creator A5053291433 @default.
- W2897655932 creator A5054646845 @default.
- W2897655932 creator A5091097481 @default.
- W2897655932 date "2018-07-01" @default.
- W2897655932 modified "2023-10-16" @default.
- W2897655932 title "IC‐P‐055: REGIONAL PATTERNS OF TAU DEPOSITION DRIVEN BY LOCAL AMYLOID ACCUMULATION RECAPITULATE BRAAK STAGES IN AD" @default.
- W2897655932 doi "https://doi.org/10.1016/j.jalz.2018.06.2120" @default.
- W2897655932 hasPublicationYear "2018" @default.
- W2897655932 type Work @default.
- W2897655932 sameAs 2897655932 @default.
- W2897655932 citedByCount "0" @default.
- W2897655932 crossrefType "journal-article" @default.
- W2897655932 hasAuthorship W2897655932A5004968642 @default.
- W2897655932 hasAuthorship W2897655932A5006091170 @default.
- W2897655932 hasAuthorship W2897655932A5008077492 @default.
- W2897655932 hasAuthorship W2897655932A5009612708 @default.
- W2897655932 hasAuthorship W2897655932A5020509082 @default.
- W2897655932 hasAuthorship W2897655932A5026681917 @default.
- W2897655932 hasAuthorship W2897655932A5034862340 @default.
- W2897655932 hasAuthorship W2897655932A5036473548 @default.
- W2897655932 hasAuthorship W2897655932A5043890316 @default.
- W2897655932 hasAuthorship W2897655932A5048432926 @default.
- W2897655932 hasAuthorship W2897655932A5053291433 @default.
- W2897655932 hasAuthorship W2897655932A5054646845 @default.
- W2897655932 hasAuthorship W2897655932A5091097481 @default.
- W2897655932 hasConcept C126838900 @default.
- W2897655932 hasConcept C142724271 @default.
- W2897655932 hasConcept C143409427 @default.
- W2897655932 hasConcept C199374082 @default.
- W2897655932 hasConcept C207886595 @default.
- W2897655932 hasConcept C2775842073 @default.
- W2897655932 hasConcept C2777633098 @default.
- W2897655932 hasConcept C2779134260 @default.
- W2897655932 hasConcept C2779951007 @default.
- W2897655932 hasConcept C2781073650 @default.
- W2897655932 hasConcept C2984915365 @default.
- W2897655932 hasConcept C2989005 @default.
- W2897655932 hasConcept C39313694 @default.
- W2897655932 hasConcept C54170458 @default.
- W2897655932 hasConcept C71924100 @default.
- W2897655932 hasConceptScore W2897655932C126838900 @default.
- W2897655932 hasConceptScore W2897655932C142724271 @default.
- W2897655932 hasConceptScore W2897655932C143409427 @default.
- W2897655932 hasConceptScore W2897655932C199374082 @default.
- W2897655932 hasConceptScore W2897655932C207886595 @default.
- W2897655932 hasConceptScore W2897655932C2775842073 @default.
- W2897655932 hasConceptScore W2897655932C2777633098 @default.
- W2897655932 hasConceptScore W2897655932C2779134260 @default.
- W2897655932 hasConceptScore W2897655932C2779951007 @default.
- W2897655932 hasConceptScore W2897655932C2781073650 @default.
- W2897655932 hasConceptScore W2897655932C2984915365 @default.
- W2897655932 hasConceptScore W2897655932C2989005 @default.
- W2897655932 hasConceptScore W2897655932C39313694 @default.
- W2897655932 hasConceptScore W2897655932C54170458 @default.
- W2897655932 hasConceptScore W2897655932C71924100 @default.
- W2897655932 hasIssue "7S_Part_1" @default.
- W2897655932 hasLocation W28976559321 @default.
- W2897655932 hasOpenAccess W2897655932 @default.
- W2897655932 hasPrimaryLocation W28976559321 @default.
- W2897655932 hasRelatedWork W2004928237 @default.
- W2897655932 hasRelatedWork W2026221058 @default.
- W2897655932 hasRelatedWork W2081549706 @default.
- W2897655932 hasRelatedWork W2134721386 @default.
- W2897655932 hasRelatedWork W2157984027 @default.
- W2897655932 hasRelatedWork W2186251212 @default.
- W2897655932 hasRelatedWork W2318587403 @default.
- W2897655932 hasRelatedWork W2405635923 @default.
- W2897655932 hasRelatedWork W3021735676 @default.
- W2897655932 hasRelatedWork W4243649116 @default.
- W2897655932 hasVolume "14" @default.
- W2897655932 isParatext "false" @default.
- W2897655932 isRetracted "false" @default.
- W2897655932 magId "2897655932" @default.
- W2897655932 workType "article" @default.