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- W2897660784 endingPage "e2005722" @default.
- W2897660784 startingPage "e2005722" @default.
- W2897660784 abstract "The value of rewards arises from multiple hedonic and motivational dimensions. Reward-encoding brain regions such as the ventral striatum (VS) are known to process these dimensions. However, the mechanism whereby distinct reward dimensions are selected for neural processing and guiding behavior remains unclear. Here, we used functional imaging to investigate how human individuals make either hedonic (liking) or motivational (wanting) evaluations of everyday items. We found that the two types of evaluations were differently modulated depending on whether participants won or lost these items. Neural activity in the VS encoded both hedonic and motivational dimensions of reward, whereas ventromedial prefrontal activity encoded primarily motivational evaluations and central orbitofrontal activity encoded predominantly hedonic evaluations. These distinct prefrontal representations arose regardless of which judgment was currently relevant for behavior. Critically, the VS preferentially processed the reward dimension currently being evaluated and showed judgment-specific functional connectivity with the dimension-specific prefrontal areas. Thus, our data are in line with a gating mechanism by which prefrontal cortex (PFC)-VS pathways flexibly encode reward dimensions depending on their behavioral relevance. These findings provide a prototype for a generalized information selection mechanism through content-tailored frontostriatal communication." @default.
- W2897660784 created "2018-10-26" @default.
- W2897660784 creator A5006100457 @default.
- W2897660784 creator A5040174058 @default.
- W2897660784 creator A5071295954 @default.
- W2897660784 creator A5072957500 @default.
- W2897660784 date "2018-10-19" @default.
- W2897660784 modified "2023-10-14" @default.
- W2897660784 title "Frontostriatal pathways gate processing of behaviorally relevant reward dimensions" @default.
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- W2897660784 doi "https://doi.org/10.1371/journal.pbio.2005722" @default.
- W2897660784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6209378" @default.
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- W2897660784 hasPublicationYear "2018" @default.
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