FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897662783> ?p ?o ?g. }

• W2897662783 endingPage "350" @default.
• W2897662783 startingPage "350" @default.
• W2897662783 abstract "As a common brain cancer derived from glial cells, gliomas have three subtypes: glioblastoma, diffuse astrocytoma, and anaplastic astrocytoma. The subtypes have distinctive clinical features but are closely related to each other. A glioblastoma can be derived from the early stage of diffuse astrocytoma, which can be transformed into anaplastic astrocytoma. Due to the complexity of these dynamic processes, single-cell gene expression profiles are extremely helpful to understand what defines these subtypes. We analyzed the single-cell gene expression profiles of 5057 cells of anaplastic astrocytoma tissues, 261 cells of diffuse astrocytoma tissues, and 1023 cells of glioblastoma tissues with advanced machine learning methods. In detail, a powerful feature selection method, Monte Carlo feature selection (MCFS) method, was adopted to analyze the gene expression profiles of cells, resulting in a feature list. Then, the incremental feature selection (IFS) method was applied to the obtained feature list, with the help of support vector machine (SVM), to extract key features (genes) and construct an optimal SVM classifier. Several key biomarker genes, such as IGFBP2, IGF2BP3, PRDX1, NOV, NEFL, HOXA10, GNG12, SPRY4, and BCL11A, were identified. In addition, the underlying rules of classifying the three subtypes were produced by Johnson reducer algorithm. We found that in diffuse astrocytoma, PRDX1 is highly expressed, and in glioblastoma, the expression level of PRDX1 is low. These rules revealed the difference among the three subtypes, and how they are formed and transformed. These genes are not only biomarkers for glioma subtypes, but also drug targets that may switch the clinical features or even reverse the tumor progression." @default.
• W2897662783 created "2018-10-26" @default.
• W2897662783 creator A5008083038 @default.
• W2897662783 creator A5025077602 @default.
• W2897662783 creator A5028019626 @default.
• W2897662783 creator A5046736908 @default.
• W2897662783 creator A5052775691 @default.
• W2897662783 creator A5064600744 @default.
• W2897662783 creator A5066807605 @default.
• W2897662783 creator A5076748700 @default.
• W2897662783 date "2018-10-13" @default.
• W2897662783 modified "2023-09-25" @default.
• W2897662783 title "Identification of the Gene Expression Rules That Define the Subtypes in Glioma" @default.
• W2897662783 cites W1506552881 @default.
• W2897662783 cites W1567033121 @default.
• W2897662783 cites W1656032348 @default.
• W2897662783 cites W1901736351 @default.
• W2897662783 cites W1951630905 @default.
• W2897662783 cites W1965479333 @default.
• W2897662783 cites W1973706702 @default.
• W2897662783 cites W1975584280 @default.
• W2897662783 cites W1985323012 @default.
• W2897662783 cites W1985366775 @default.
• W2897662783 cites W1985606337 @default.
• W2897662783 cites W1988070337 @default.
• W2897662783 cites W1989397563 @default.
• W2897662783 cites W1990377901 @default.
• W2897662783 cites W1991765483 @default.
• W2897662783 cites W2000237898 @default.
• W2897662783 cites W2002554105 @default.
• W2897662783 cites W2003019330 @default.
• W2897662783 cites W2006111516 @default.
• W2897662783 cites W2007949444 @default.
• W2897662783 cites W2016721805 @default.
• W2897662783 cites W2019683307 @default.
• W2897662783 cites W2019685247 @default.
• W2897662783 cites W2025463427 @default.
• W2897662783 cites W2042080146 @default.
• W2897662783 cites W2046771593 @default.
• W2897662783 cites W2055475004 @default.
• W2897662783 cites W2059185913 @default.
• W2897662783 cites W2073278656 @default.
• W2897662783 cites W2073698327 @default.
• W2897662783 cites W2080500945 @default.
• W2897662783 cites W2083916407 @default.
• W2897662783 cites W2090577904 @default.
• W2897662783 cites W2092969708 @default.
• W2897662783 cites W2094427045 @default.
• W2897662783 cites W2095344194 @default.
• W2897662783 cites W2103635561 @default.
• W2897662783 cites W2108625512 @default.
• W2897662783 cites W2109553965 @default.
• W2897662783 cites W2116459725 @default.
• W2897662783 cites W2124117141 @default.
• W2897662783 cites W2133567825 @default.
• W2897662783 cites W2134807618 @default.
• W2897662783 cites W2138336030 @default.
• W2897662783 cites W2160687134 @default.
• W2897662783 cites W2164890947 @default.
• W2897662783 cites W2165079404 @default.
• W2897662783 cites W2169883682 @default.
• W2897662783 cites W2171195745 @default.
• W2897662783 cites W2220215167 @default.
• W2897662783 cites W2225079860 @default.
• W2897662783 cites W2236416891 @default.
• W2897662783 cites W2237741935 @default.
• W2897662783 cites W2257254975 @default.
• W2897662783 cites W228600387 @default.
• W2897662783 cites W2301231318 @default.
• W2897662783 cites W2328437933 @default.
• W2897662783 cites W2334436911 @default.
• W2897662783 cites W2396875676 @default.
• W2897662783 cites W2414403668 @default.
• W2897662783 cites W2427753924 @default.
• W2897662783 cites W2472670016 @default.
• W2897662783 cites W2484222071 @default.
• W2897662783 cites W2546514099 @default.
• W2897662783 cites W2574386421 @default.
• W2897662783 cites W2603523955 @default.
• W2897662783 cites W2732357513 @default.
• W2897662783 cites W2751584274 @default.
• W2897662783 cites W2754896703 @default.
• W2897662783 cites W2767517505 @default.
• W2897662783 cites W2770474929 @default.
• W2897662783 cites W2781221182 @default.
• W2897662783 cites W2799718261 @default.
• W2897662783 cites W2806655114 @default.
• W2897662783 cites W2895757710 @default.
• W2897662783 cites W30336109 @default.
• W2897662783 cites W315258854 @default.
• W2897662783 cites W4239510810 @default.
• W2897662783 cites W822925533 @default.
• W2897662783 cites W2020385880 @default.
• W2897662783 doi "https://doi.org/10.3390/jcm7100350" @default.
• W2897662783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6210469" @default.
• W2897662783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30322114" @default.
• W2897662783 hasPublicationYear "2018" @default.
• W2897662783 type Work @default.

• next