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- W2897664712 abstract "Bilingualism has been suggested to delay the onset of Alzheimeŕs Disease (AD) and has been identified as a proxy of cognitive reserve. Our group has previously shown, employing MEG, how bilingual healthy elders exhibit greater functional connectivity between several brain regions, which could possibly be interpreted as a sign of greater cognitive reserve. ApoE ε4 carriers are at increased risk for developing AD. Therefore we aim to study if ApoE ε4 carriage modulates the relationship between bilingualism and brain functional connectivity in a sample of healthy older adults. 65 healthy older adults participated in the study (aging <65).The sample included 19 late sequential bilinguals non-carriers, 11 sequential bilingual carriers, 22 monolingual non-carriers and 12 monolingual carriers. We estimated functional connectivity using phase-locking value in the theta, alpha, beta1 and beta2 bands in 4 minutes eyes closed resting recordings. ApoE haplotype was determined by analyzing SNPs rs7412 and rs429358 genotypes with TaqMan assays. Only ε3ε3 individuals (non-carriers) and ε3ε4 individuals (carriers) were included in the final sample. A 2x2 ANOVA revealed that bilinguals exhibited greater functional connectivity than monolinguals between several fronto-temporal regions (p=0.040). No significant effects of ApoE carriage emerged. This is, to the best of our knowledge, the first time that ApoE ε4 carriage has been studied as a potential modulator of the relationship between bilingualism and an AD marker. Our results suggest that bilingualism exerts an influential effect on the functional networks of the brain, but such effect is not modulated by ApoE status. Hence we conclude that in healthy older adults ApoE ε4 carriage does not impair the neuroplasticity mechanisms that enable the neurophysiological remodelling effect of bilingualism. We are currently working on enlarging the sample to foster deeper understanding of this topic." @default.
- W2897664712 created "2018-10-26" @default.
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- W2897664712 date "2018-07-01" @default.
- W2897664712 modified "2023-10-16" @default.
- W2897664712 title "P1‐641: GENETIC RISK FOR ALZHEIMER'S AND BILINGUALISM: AN MEG STUDY" @default.
- W2897664712 doi "https://doi.org/10.1016/j.jalz.2018.06.653" @default.
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