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- W2897668137 abstract "Aged dogs demonstrate several parallels with Alzheimer's disease including both domain-specific cognitive decline and neuropathological changes. Moreover, canine aging is associated with biomarker signature patterns that are consistent with Alzheimer's disease progression. Therefore aged dogs can be used for preclinical evaluation of therapeutics under development for Alzheimer's disease. The current study sought to evaluate the effectiveness of supplementation with a novel lipid extract (Bioiberica S.A.U., Barcelona, Spain) on improving or attenuating cognitive deficits in aged Beagle dogs and improving biomarkers related to Alzheimer's disease progression. Performance across discrimination learning, delayed non-matching to position (DNMP) and selective attention tasks were used to establish two cognitively-balanced groups of aged Beagle dogs (N=12 per group) at baseline. Dogs received either a formulation containing a proprietary lipid extract (Bioiberica S.A.U., Barcelona, Spain), or a placebo control, in a gelatin capsule daily for 6 months by oral administration. Changes in cognitive function were evaluated using the DNMP, selective attention, discrimination retention, reversal learning and spatial discrimination and reversal learning tasks. Additionally, treatment effects on brain metabolism was assessed with magnetic resonance imaging (MRS) both at baseline and six months following treatment. A significant (p=0.02) decline in DNMP performance was seen in placebo-treated dogs, but not in dogs receiving the supplement. This suggests that the treatment attenuated short-term memory decline that occurs over several months in aged dogs. The supplement group also demonstrated significantly (p=0.01) improved performance on the most difficult spatial discrimination and reversal task pattern and on reversal learning (p=0.04) compared to placebo, which reflects improved executive function. Magnetic resonance spectroscopy revealed a significant (p=0.048) increase in frontal lobe glutamate and glutamine in the treatment group compared to placebo. The oral administration of a novel lipid extract for six months in aged dogs showed beneficial effects on cognitive function, especially attenuating memory decline and improving executive function, which encourages further testing of this novel lipid extract as a potential tool for the management of Alzheimer's disease." @default.
- W2897668137 created "2018-10-26" @default.
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- W2897668137 date "2018-07-01" @default.
- W2897668137 modified "2023-10-16" @default.
- W2897668137 title "P4‐214: SUPPLEMENTATION WITH A NOVEL LIPID EXTRACT IMPROVES FRONTAL LOBE LINKED COGNITIVE DEFICITS IN AN AGED BEAGLE MODEL OF ALZHEIMER'S DISEASE" @default.
- W2897668137 doi "https://doi.org/10.1016/j.jalz.2018.07.035" @default.
- W2897668137 hasPublicationYear "2018" @default.
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