Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897674394> ?p ?o ?g. }
- W2897674394 endingPage "1385" @default.
- W2897674394 startingPage "1375" @default.
- W2897674394 abstract "Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and long-term oxygen therapy has been shown to reduce mortality in COPD patients with severe hypoxemia. However, the Long-term Oxygen Treatment Trial (LOTT), a large randomized trial, found no benefit of oxygen therapy in COPD patients with moderate hypoxemia. We hypothesized that there may be differences in response to oxygen which depend on genotype or gene expression. In a genome-wide time-to-event analysis of the primary outcome of death or hospitalization in 331 subjects, 97 single nucleotide polymorphisms (SNPs) showed evidence of interaction with oxygen therapy at P < 1e−5, including 7 SNPs near arylsulfatase B (ARSB; P = 6e−6). In microarray expression profiling on 51 whole blood samples from 37 individuals, at screening and/or at 12-month follow-up, ARSB expression was associated with the primary outcome depending on oxygen treatment. The significant SNPs were conditional expression quantitative trait loci for ARSB expression. In a network analysis of genes affected by long-term oxygen, two observed clusters including 26 co-expressed genes were enriched in mitochondrial function. Using data from the observational COPDGene Study, we validated the expression of 25 of these 26 genes, plus ARSB. The effect of long-term oxygen therapy in COPD varied based on ARSB expression and genotype. ARSB has previously been shown to be associated with hypoxemia in human bronchial and colonic epithelial cells and in a mouse model. In peripheral blood, long-term oxygen treatment affected expression of mitochondrial-related genes, a biologically relevant pathway in COPD. SNPs and expression of ARSB are associated with response to long-term oxygen in COPD. The ARSB SNPs were expression quantitative trait loci depending on oxygen therapy. Genes differentially expressed by long-term oxygen were enriched in mitochondrial functions. This suggests a potential biomarker to personalize use of long-term oxygen in COPD." @default.
- W2897674394 created "2018-10-26" @default.
- W2897674394 creator A5003851805 @default.
- W2897674394 creator A5009003396 @default.
- W2897674394 creator A5010313245 @default.
- W2897674394 creator A5018495347 @default.
- W2897674394 creator A5021098628 @default.
- W2897674394 creator A5025950806 @default.
- W2897674394 creator A5027893019 @default.
- W2897674394 creator A5035524361 @default.
- W2897674394 creator A5039465149 @default.
- W2897674394 creator A5045141623 @default.
- W2897674394 creator A5050358373 @default.
- W2897674394 creator A5052479679 @default.
- W2897674394 creator A5058359938 @default.
- W2897674394 creator A5059655447 @default.
- W2897674394 creator A5074971535 @default.
- W2897674394 creator A5075425205 @default.
- W2897674394 creator A5083798425 @default.
- W2897674394 creator A5091422877 @default.
- W2897674394 date "2018-10-23" @default.
- W2897674394 modified "2023-10-18" @default.
- W2897674394 title "Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease" @default.
- W2897674394 cites W1996711072 @default.
- W2897674394 cites W1996996288 @default.
- W2897674394 cites W2002237351 @default.
- W2897674394 cites W2005623173 @default.
- W2897674394 cites W2006696253 @default.
- W2897674394 cites W2008481858 @default.
- W2897674394 cites W2021460489 @default.
- W2897674394 cites W2033750705 @default.
- W2897674394 cites W2037621565 @default.
- W2897674394 cites W2038713498 @default.
- W2897674394 cites W2045616259 @default.
- W2897674394 cites W2060578352 @default.
- W2897674394 cites W2066569687 @default.
- W2897674394 cites W2080973457 @default.
- W2897674394 cites W2094869059 @default.
- W2897674394 cites W2097795961 @default.
- W2897674394 cites W2104875151 @default.
- W2897674394 cites W2121719876 @default.
- W2897674394 cites W2125088463 @default.
- W2897674394 cites W2131365156 @default.
- W2897674394 cites W2132692266 @default.
- W2897674394 cites W2138208423 @default.
- W2897674394 cites W2255333206 @default.
- W2897674394 cites W2339389340 @default.
- W2897674394 cites W2401964968 @default.
- W2897674394 cites W2495450286 @default.
- W2897674394 cites W2514020013 @default.
- W2897674394 cites W2538506131 @default.
- W2897674394 cites W2566579337 @default.
- W2897674394 cites W2607249259 @default.
- W2897674394 cites W2762563969 @default.
- W2897674394 cites W3101950577 @default.
- W2897674394 cites W4205209053 @default.
- W2897674394 doi "https://doi.org/10.1007/s00109-018-1708-8" @default.
- W2897674394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240374" @default.
- W2897674394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30353303" @default.
- W2897674394 hasPublicationYear "2018" @default.
- W2897674394 type Work @default.
- W2897674394 sameAs 2897674394 @default.
- W2897674394 citedByCount "14" @default.
- W2897674394 countsByYear W28976743942019 @default.
- W2897674394 countsByYear W28976743942020 @default.
- W2897674394 countsByYear W28976743942021 @default.
- W2897674394 countsByYear W28976743942022 @default.
- W2897674394 countsByYear W28976743942023 @default.
- W2897674394 crossrefType "journal-article" @default.
- W2897674394 hasAuthorship W2897674394A5003851805 @default.
- W2897674394 hasAuthorship W2897674394A5009003396 @default.
- W2897674394 hasAuthorship W2897674394A5010313245 @default.
- W2897674394 hasAuthorship W2897674394A5018495347 @default.
- W2897674394 hasAuthorship W2897674394A5021098628 @default.
- W2897674394 hasAuthorship W2897674394A5025950806 @default.
- W2897674394 hasAuthorship W2897674394A5027893019 @default.
- W2897674394 hasAuthorship W2897674394A5035524361 @default.
- W2897674394 hasAuthorship W2897674394A5039465149 @default.
- W2897674394 hasAuthorship W2897674394A5045141623 @default.
- W2897674394 hasAuthorship W2897674394A5050358373 @default.
- W2897674394 hasAuthorship W2897674394A5052479679 @default.
- W2897674394 hasAuthorship W2897674394A5058359938 @default.
- W2897674394 hasAuthorship W2897674394A5059655447 @default.
- W2897674394 hasAuthorship W2897674394A5074971535 @default.
- W2897674394 hasAuthorship W2897674394A5075425205 @default.
- W2897674394 hasAuthorship W2897674394A5083798425 @default.
- W2897674394 hasAuthorship W2897674394A5091422877 @default.
- W2897674394 hasBestOaLocation W28976743942 @default.
- W2897674394 hasConcept C104317684 @default.
- W2897674394 hasConcept C126322002 @default.
- W2897674394 hasConcept C135763542 @default.
- W2897674394 hasConcept C143998085 @default.
- W2897674394 hasConcept C153209595 @default.
- W2897674394 hasConcept C2776779939 @default.
- W2897674394 hasConcept C2776780178 @default.
- W2897674394 hasConcept C2780630273 @default.
- W2897674394 hasConcept C54355233 @default.
- W2897674394 hasConcept C60644358 @default.