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• W2897690640 abstract "Abstract Objectives Omega‐3 fatty acids are well‐known unsaturated fatty acids that are essential for growth and development in animals. They primarily participate in the development of intelligence, the nervous system, and vision, and the metabolism of neurotransmitters. Omega‐3 fatty acids have been widely studied in the treatment of Alzheimer's disease ( AD ). Omega‐3 fatty acids are known to have neuroprotective effects due to their antioxidant capacity. Rotenone has been shown to induce neurotoxicity in vitro. Methods We investigated the protective effects of omega‐3 fatty acids against AD in rat brain microvascular endothelial cells ( RBMVEC s) in vitro. Lipid peroxidation, reactive oxygen species ( ROS ), glutathione peroxidase (Gpx), reduced glutathione ( GSH ), superoxide dismutase ( SOD ), and catalase levels were evaluated in RBMVEC s. Flow cytometry was performed to assess apoptosis. Results Lipid peroxidation and ROS were reduced in RBMVEC s following incubation with omega‐3 fatty acids. Catalase, Gpx, and SOD were increased in RBMVEC s following incubation with omega‐3 fatty acids. Flow cytometry showed that incubation with omega‐3 fatty acids reduced the amount of apoptotic RBMVEC s. Conclusion Our results suggest that omega‐3 fatty acids show potential as a therapeutic agent against AD ." @default.
• W2897690640 created "2018-10-26" @default.
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• W2897690640 date "2018-10-08" @default.
• W2897690640 modified "2023-10-17" @default.
• W2897690640 title "Protective effects of omega-3 fatty acids against Alzheimer's disease in rat brain endothelial cells" @default.
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• W2897690640 doi "https://doi.org/10.1002/brb3.1037" @default.
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