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- W2897700601 abstract "CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids and are widely employed as genome editing tools. These tools use RNA-guided Cas proteins whose large size (950 to 1400 amino acids) has been considered essential to their specific DNA- or RNA-targeting activities. Here we present a set of CRISPR-Cas systems from uncultivated archaea that contain Cas14, a family of exceptionally compact RNA-guided nucleases (400 to 700 amino acids). Despite their small size, Cas14 proteins are capable of targeted single-stranded DNA (ssDNA) cleavage without restrictive sequence requirements. Moreover, target recognition by Cas14 triggers nonspecific cutting of ssDNA molecules, an activity that enables high-fidelity single-nucleotide polymorphism genotyping (Cas14-DETECTR). Metagenomic data show that multiple CRISPR-Cas14 systems evolved independently and suggest a potential evolutionary origin of single-effector CRISPR-based adaptive immunity." @default.
- W2897700601 created "2018-10-26" @default.
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- W2897700601 date "2018-11-16" @default.
- W2897700601 modified "2023-10-17" @default.
- W2897700601 title "Programmed DNA destruction by miniature CRISPR-Cas14 enzymes" @default.
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- W2897700601 doi "https://doi.org/10.1126/science.aav4294" @default.
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