Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897701037> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2897701037 abstract "Introduction. The local delivery of therapeutic antibiotic concentrations to the zone of surgical intervention in bone pathology enables either to prevent or significantly decrease the rate of osteomyelitis development. It that study the efficacy of vancomycin inclusion and release from three dimensional constructors based on sodium alginate, gelatin and octacalcium phosphate and vancomycin intended for bone defect substitution was studied. Materials and methods . Prototyping of 3D constructors was performed by extrusion 3D printing. Various concentrations of vancomycin were added as an additional component at the stage of preparation of hydrogel (“ink”) for printing. Physical testing of the constructors included electron microscopic evaluation of their microstructure and porosity as well as the study of mechanical strength for compression and stretching. Functional activity of printed constructors with respect to the test strain S. aureus ATCC 6538-P was assessed by a disc-diffusion method in vitro and on the model of infected excision skin wound in rats - in vivo . Results . Analysis of the kinetic curves showed that the principal release of the drug in the model liquid took place within the first day. The total volume of the bound and released vancomycin made up approximately 20% of the calculated initial amount for all three concentrations. Formation of the marked growth inhibition zone of S. aureus strain in presence of vancomycin rich constructors was demonstrated in vitro. Insertion of constructors into the zone of infected skin defect resulted in a decrease of inflammatory processes severity and rate as well as accelerated the terms of complete wound healing. Conclusion . Study results showed the principle potentiality of bone substituting implants 3D-printing using multicomponent hydrogel compositions without change of separate components characteristics." @default.
- W2897701037 created "2018-10-26" @default.
- W2897701037 creator A5002641320 @default.
- W2897701037 creator A5051510075 @default.
- W2897701037 creator A5062004281 @default.
- W2897701037 creator A5070748334 @default.
- W2897701037 creator A5072798772 @default.
- W2897701037 creator A5073727558 @default.
- W2897701037 creator A5074777196 @default.
- W2897701037 creator A5078945815 @default.
- W2897701037 creator A5084474640 @default.
- W2897701037 creator A5090012613 @default.
- W2897701037 creator A5090060645 @default.
- W2897701037 creator A5090117836 @default.
- W2897701037 date "2017-06-30" @default.
- W2897701037 modified "2023-09-27" @default.
- W2897701037 title "Bacteriostatic Characteristics of Bone Substituting Constructors Obtained from Composite Materials Based on Natural Polymers, Calcium Phosphates and Vancomycin" @default.
- W2897701037 cites W1966830221 @default.
- W2897701037 cites W1993037781 @default.
- W2897701037 cites W2005463566 @default.
- W2897701037 cites W2017545194 @default.
- W2897701037 cites W2028313639 @default.
- W2897701037 cites W2030001975 @default.
- W2897701037 cites W2044504436 @default.
- W2897701037 cites W2060784757 @default.
- W2897701037 cites W2066224020 @default.
- W2897701037 cites W2070923512 @default.
- W2897701037 cites W2096136468 @default.
- W2897701037 cites W2118712467 @default.
- W2897701037 cites W2169724155 @default.
- W2897701037 cites W2331258735 @default.
- W2897701037 cites W2468757368 @default.
- W2897701037 cites W2538639213 @default.
- W2897701037 cites W4241470858 @default.
- W2897701037 cites W4256678545 @default.
- W2897701037 doi "https://doi.org/10.32414/0869-8678-2017-2-48-56" @default.
- W2897701037 hasPublicationYear "2017" @default.
- W2897701037 type Work @default.
- W2897701037 sameAs 2897701037 @default.
- W2897701037 citedByCount "0" @default.
- W2897701037 crossrefType "journal-article" @default.
- W2897701037 hasAuthorship W2897701037A5002641320 @default.
- W2897701037 hasAuthorship W2897701037A5051510075 @default.
- W2897701037 hasAuthorship W2897701037A5062004281 @default.
- W2897701037 hasAuthorship W2897701037A5070748334 @default.
- W2897701037 hasAuthorship W2897701037A5072798772 @default.
- W2897701037 hasAuthorship W2897701037A5073727558 @default.
- W2897701037 hasAuthorship W2897701037A5074777196 @default.
- W2897701037 hasAuthorship W2897701037A5078945815 @default.
- W2897701037 hasAuthorship W2897701037A5084474640 @default.
- W2897701037 hasAuthorship W2897701037A5090012613 @default.
- W2897701037 hasAuthorship W2897701037A5090060645 @default.
- W2897701037 hasAuthorship W2897701037A5090117836 @default.
- W2897701037 hasBestOaLocation W28977010371 @default.
- W2897701037 hasConcept C104779481 @default.
- W2897701037 hasConcept C127313418 @default.
- W2897701037 hasConcept C151730666 @default.
- W2897701037 hasConcept C159985019 @default.
- W2897701037 hasConcept C185592680 @default.
- W2897701037 hasConcept C191897082 @default.
- W2897701037 hasConcept C192562407 @default.
- W2897701037 hasConcept C2778980435 @default.
- W2897701037 hasConcept C2779489039 @default.
- W2897701037 hasConcept C2909316542 @default.
- W2897701037 hasConcept C519063684 @default.
- W2897701037 hasConcept C521977710 @default.
- W2897701037 hasConcept C523546767 @default.
- W2897701037 hasConceptScore W2897701037C104779481 @default.
- W2897701037 hasConceptScore W2897701037C127313418 @default.
- W2897701037 hasConceptScore W2897701037C151730666 @default.
- W2897701037 hasConceptScore W2897701037C159985019 @default.
- W2897701037 hasConceptScore W2897701037C185592680 @default.
- W2897701037 hasConceptScore W2897701037C191897082 @default.
- W2897701037 hasConceptScore W2897701037C192562407 @default.
- W2897701037 hasConceptScore W2897701037C2778980435 @default.
- W2897701037 hasConceptScore W2897701037C2779489039 @default.
- W2897701037 hasConceptScore W2897701037C2909316542 @default.
- W2897701037 hasConceptScore W2897701037C519063684 @default.
- W2897701037 hasConceptScore W2897701037C521977710 @default.
- W2897701037 hasConceptScore W2897701037C523546767 @default.
- W2897701037 hasLocation W28977010371 @default.
- W2897701037 hasOpenAccess W2897701037 @default.
- W2897701037 hasPrimaryLocation W28977010371 @default.
- W2897701037 hasRelatedWork W1610732643 @default.
- W2897701037 hasRelatedWork W2061476470 @default.
- W2897701037 hasRelatedWork W3130900537 @default.
- W2897701037 hasRelatedWork W3196103081 @default.
- W2897701037 hasRelatedWork W2871919096 @default.
- W2897701037 isParatext "false" @default.
- W2897701037 isRetracted "false" @default.
- W2897701037 magId "2897701037" @default.
- W2897701037 workType "article" @default.