Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897712823> ?p ?o ?g. }
- W2897712823 endingPage "e3129" @default.
- W2897712823 startingPage "e3129" @default.
- W2897712823 abstract "Eight molecules, four peptides (SPs) and four lipopeptides (LPs) derived by rational design from surfactin, a well-known secreted biosurfactant from Bacillus subtilis, were produced employing Fmoc-based solid-phase synthesis. These new peptides were tested to evaluate their potential biosurfactant and biological activities, aiming at possible applications in industrial, biological, pharmaceutical, and medical use. Five molecules (SP1, SP2, SP4, LP5, and LP8) presented potential for medical uses, mainly due to their drug delivery properties as suggested by their synergistic activity with the antibiotic vancomycin against Staphylococcus aureus. All synthetic peptides showed low toxicity against Vero cell cultures, in assays of hemolysis, and in different cytotoxicity assays. In addition, we found that three peptides (SP1, LP6, and LP7) had potential technological and industrial use because of their emulsifying capacity, low toxicity, and ability to physically stabilize solutions. These novel molecules retained some properties of the parental molecule (surfactin, which was originally obtained through nonribosomal synthesis in Bacillus subtilis) but have the advantage of being linear peptides, which can be produced at large scales through the use of conventional heterologous protein expression protocols." @default.
- W2897712823 created "2018-10-26" @default.
- W2897712823 creator A5007745831 @default.
- W2897712823 creator A5013116955 @default.
- W2897712823 creator A5041767886 @default.
- W2897712823 creator A5052077736 @default.
- W2897712823 creator A5069134264 @default.
- W2897712823 creator A5073024512 @default.
- W2897712823 creator A5078027602 @default.
- W2897712823 creator A5086854258 @default.
- W2897712823 creator A5087019763 @default.
- W2897712823 date "2018-10-16" @default.
- W2897712823 modified "2023-09-24" @default.
- W2897712823 title "Properties of novel surfactin-derived biosurfactants obtained through solid-phase synthesis" @default.
- W2897712823 cites W1191950147 @default.
- W2897712823 cites W1489730593 @default.
- W2897712823 cites W1531654029 @default.
- W2897712823 cites W1558211128 @default.
- W2897712823 cites W1683883396 @default.
- W2897712823 cites W1730500298 @default.
- W2897712823 cites W1942176292 @default.
- W2897712823 cites W1972318851 @default.
- W2897712823 cites W1976081311 @default.
- W2897712823 cites W1985342306 @default.
- W2897712823 cites W1985381418 @default.
- W2897712823 cites W1995535725 @default.
- W2897712823 cites W1996143507 @default.
- W2897712823 cites W1997325165 @default.
- W2897712823 cites W2011571123 @default.
- W2897712823 cites W2019816897 @default.
- W2897712823 cites W2027542963 @default.
- W2897712823 cites W2043637175 @default.
- W2897712823 cites W2044400068 @default.
- W2897712823 cites W2051786708 @default.
- W2897712823 cites W2064336821 @default.
- W2897712823 cites W2068534776 @default.
- W2897712823 cites W2071461119 @default.
- W2897712823 cites W2071869626 @default.
- W2897712823 cites W2080433928 @default.
- W2897712823 cites W2082816719 @default.
- W2897712823 cites W2084303103 @default.
- W2897712823 cites W2084911770 @default.
- W2897712823 cites W2087404628 @default.
- W2897712823 cites W2089606209 @default.
- W2897712823 cites W2090288316 @default.
- W2897712823 cites W2111776523 @default.
- W2897712823 cites W2112355707 @default.
- W2897712823 cites W2123461393 @default.
- W2897712823 cites W2128245530 @default.
- W2897712823 cites W2137992445 @default.
- W2897712823 cites W2138023605 @default.
- W2897712823 cites W2168526937 @default.
- W2897712823 cites W2171168121 @default.
- W2897712823 cites W2172208236 @default.
- W2897712823 cites W2202271786 @default.
- W2897712823 cites W2274550965 @default.
- W2897712823 cites W2285385558 @default.
- W2897712823 cites W2299309519 @default.
- W2897712823 cites W2337777524 @default.
- W2897712823 cites W2415396009 @default.
- W2897712823 cites W2503348119 @default.
- W2897712823 cites W2510890404 @default.
- W2897712823 cites W2549836338 @default.
- W2897712823 cites W2609004725 @default.
- W2897712823 cites W2620480471 @default.
- W2897712823 cites W2626184818 @default.
- W2897712823 cites W2735800947 @default.
- W2897712823 cites W952639005 @default.
- W2897712823 doi "https://doi.org/10.1002/psc.3129" @default.
- W2897712823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30325566" @default.
- W2897712823 hasPublicationYear "2018" @default.
- W2897712823 type Work @default.
- W2897712823 sameAs 2897712823 @default.
- W2897712823 citedByCount "4" @default.
- W2897712823 countsByYear W28977128232020 @default.
- W2897712823 countsByYear W28977128232021 @default.
- W2897712823 countsByYear W28977128232023 @default.
- W2897712823 crossrefType "journal-article" @default.
- W2897712823 hasAuthorship W2897712823A5007745831 @default.
- W2897712823 hasAuthorship W2897712823A5013116955 @default.
- W2897712823 hasAuthorship W2897712823A5041767886 @default.
- W2897712823 hasAuthorship W2897712823A5052077736 @default.
- W2897712823 hasAuthorship W2897712823A5069134264 @default.
- W2897712823 hasAuthorship W2897712823A5073024512 @default.
- W2897712823 hasAuthorship W2897712823A5078027602 @default.
- W2897712823 hasAuthorship W2897712823A5086854258 @default.
- W2897712823 hasAuthorship W2897712823A5087019763 @default.
- W2897712823 hasConcept C104317684 @default.
- W2897712823 hasConcept C109316439 @default.
- W2897712823 hasConcept C185592680 @default.
- W2897712823 hasConcept C202751555 @default.
- W2897712823 hasConcept C21951064 @default.
- W2897712823 hasConcept C2776102837 @default.
- W2897712823 hasConcept C2777272437 @default.
- W2897712823 hasConcept C2779281246 @default.
- W2897712823 hasConcept C2780115692 @default.
- W2897712823 hasConcept C523546767 @default.
- W2897712823 hasConcept C540938839 @default.