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• W2897713779 abstract "Lonicera japonica Thunb., possesses antiviral and hepatoprotective activities, and is widely used as a health food and in cosmetics. However, its major constituents, caffeoylquinic acid derivatives, and their anti-HBV activity were lacking systematic research. In this study, four novel caffeoylquinic acids, five simple caffeic acids and fourteen known caffeoylquinic acids are isolated and identified from L. japonica. Most caffeoylquinic acids inhibited HBsAg and HBeAg secretion, and HBV DNA replication. In particular, 100 μg ml-1 monocaffeoylquinic acid 9 inhibits HBsAg and HBeAg secretion, and HBV DNA replication by 83.82, 70.76 and 39.36% compared to the control. Unfortunately, 50 μg ml-1 tricaffeoylquinic acid 23 promotes HBsAg and HBeAg secretion, and HBV DNA replication by 172.39, 9.92 and 55.40%. Finally, structure-activity relationships reveal that caffeoylquinic acids containing a caffeoyl group have better inhibitory activities. The results indicate that caffeoylquinic acids from L. japonica could serve as anti-HBV agents for functional food or medicinal use." @default.
• W2897713779 created "2018-10-26" @default.
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• W2897713779 date "2018-01-01" @default.
• W2897713779 modified "2023-10-16" @default.
• W2897713779 title "Novel caffeoylquinic acid derivatives from <i>Lonicera japonica</i> Thunb. flower buds exert pronounced anti-HBV activities" @default.
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• W2897713779 doi "https://doi.org/10.1039/c8ra07549b" @default.
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