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• W2897716152 abstract "Significance Blood-oxygen-level-dependent (BOLD) fMRI has proven to be extremely powerful for studying brain function, but is essentially limited to applications in gray matter. This work investigates the underlying mechanisms responsible for MRI-based signal changes in myelinated axonal fibers of perfused bullfrog sciatic nerves. Simultaneous in-magnet recording of compound action potentials (CAPs) and MRI data acquisition reveal that the diffusion fMRI response is linearly proportional to the number of electrical impulses. Increased restricted diffusion fraction (from diffusion basis spectrum imaging) could be related to submyelinic vacuole formation observed by electron microscopy of perfused nerves fixed resting or undergoing stimulation. Microstructural changes and osmotically driven redistribution of tissue water play a crucial role in the observed diffusion fMRI response in myelinated fibers." @default.
• W2897716152 created "2018-10-26" @default.
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• W2897716152 date "2018-10-08" @default.
• W2897716152 modified "2023-09-26" @default.
• W2897716152 title "MRI-based assessment of function and dysfunction in myelinated axons" @default.
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• W2897716152 doi "https://doi.org/10.1073/pnas.1801788115" @default.
• W2897716152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205472" @default.
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