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• W2897716194 endingPage "e1007784" @default.
• W2897716194 startingPage "e1007784" @default.
• W2897716194 abstract "Endogenous small RNAs (sRNAs) and Argonaute proteins are ubiquitous regulators of gene expression in germline and somatic tissues. sRNA-Argonaute complexes are often expressed in gametes and are consequently inherited by the next generation upon fertilization. In Caenorhabditis elegans, 26G-RNAs are primary endogenous sRNAs that trigger the expression of downstream secondary sRNAs. Two subpopulations of 26G-RNAs exist, each of which displaying strongly compartmentalized expression: one is expressed in the spermatogenic gonad and associates with the Argonautes ALG-3/4; plus another expressed in oocytes and in embryos, which associates with the Argonaute ERGO-1. The determinants and dynamics of gene silencing elicited by 26G-RNAs are largely unknown. Here, we provide diverse new insights into these endogenous sRNA pathways of C. elegans. Using genetics and deep sequencing, we dissect a maternal effect of the ERGO-1 branch of the 26G-RNA pathway. We find that maternal primary sRNAs can trigger the production of zygotic secondary sRNAs that are able to silence targets, even in the absence of zygotic primary triggers. Thus, the interaction of maternal and zygotic sRNA populations, assures target gene silencing throughout animal development. Furthermore, we explore other facets of 26G-RNA biology related to the ALG-3/4 branch. We find that sRNA abundance, sRNA pattern of origin and the 3’ UTR length of target transcripts are predictors of the regulatory outcome by the Argonautes ALG-3/4. Lastly, we provide evidence suggesting that ALG-3 and ALG-4 regulate their own mRNAs in a negative feedback loop. Altogether, we provide several new regulatory insights on the dynamics, target regulation and self-regulation of the endogenous RNAi pathways of C. elegans." @default.
• W2897716194 created "2018-10-26" @default.
• W2897716194 creator A5004169647 @default.
• W2897716194 creator A5028745417 @default.
• W2897716194 creator A5060430028 @default.
• W2897716194 date "2019-02-13" @default.
• W2897716194 modified "2023-09-26" @default.
• W2897716194 title "Maternal and zygotic gene regulatory effects of endogenous RNAi pathways" @default.
• W2897716194 cites W1647075334 @default.
• W2897716194 cites W1816943760 @default.
• W2897716194 cites W1861196385 @default.
• W2897716194 cites W1932581232 @default.
• W2897716194 cites W1944127002 @default.
• W2897716194 cites W1965365401 @default.
• W2897716194 cites W1965532812 @default.
• W2897716194 cites W1969719291 @default.
• W2897716194 cites W1969865366 @default.
• W2897716194 cites W1970679013 @default.
• W2897716194 cites W1976342457 @default.
• W2897716194 cites W1987908533 @default.
• W2897716194 cites W1991007428 @default.
• W2897716194 cites W1993907364 @default.
• W2897716194 cites W1995048848 @default.
• W2897716194 cites W1996293707 @default.
• W2897716194 cites W2006247279 @default.
• W2897716194 cites W2027610589 @default.
• W2897716194 cites W2027891004 @default.
• W2897716194 cites W2030071264 @default.
• W2897716194 cites W2033518550 @default.
• W2897716194 cites W2034293536 @default.
• W2897716194 cites W2036897871 @default.
• W2897716194 cites W2038492783 @default.
• W2897716194 cites W2040058302 @default.
• W2897716194 cites W2057558367 @default.
• W2897716194 cites W2059037240 @default.
• W2897716194 cites W2062688476 @default.
• W2897716194 cites W2063775754 @default.
• W2897716194 cites W2068271232 @default.
• W2897716194 cites W2068711892 @default.
• W2897716194 cites W2068847708 @default.
• W2897716194 cites W2069433314 @default.
• W2897716194 cites W2081056565 @default.
• W2897716194 cites W2082578963 @default.
• W2897716194 cites W2098756183 @default.
• W2897716194 cites W2100336754 @default.
• W2897716194 cites W2102619694 @default.
• W2897716194 cites W2107961632 @default.
• W2897716194 cites W2108234281 @default.
• W2897716194 cites W2111217101 @default.
• W2897716194 cites W2117661095 @default.
• W2897716194 cites W2122984483 @default.
• W2897716194 cites W2124134646 @default.
• W2897716194 cites W2124774982 @default.
• W2897716194 cites W2124985265 @default.
• W2897716194 cites W2126985046 @default.
• W2897716194 cites W2128746033 @default.
• W2897716194 cites W2131852558 @default.
• W2897716194 cites W2132102978 @default.
• W2897716194 cites W2134424319 @default.
• W2897716194 cites W2134526812 @default.
• W2897716194 cites W2138207763 @default.
• W2897716194 cites W2138910750 @default.
• W2897716194 cites W2143634826 @default.
• W2897716194 cites W2147149702 @default.
• W2897716194 cites W2154222068 @default.
• W2897716194 cites W2155396586 @default.
• W2897716194 cites W2166867324 @default.
• W2897716194 cites W2167999293 @default.
• W2897716194 cites W2168285793 @default.
• W2897716194 cites W2169619536 @default.
• W2897716194 cites W2179438025 @default.
• W2897716194 cites W2195136000 @default.
• W2897716194 cites W2304223632 @default.
• W2897716194 cites W2306536993 @default.
• W2897716194 cites W2341539131 @default.
• W2897716194 cites W2575585019 @default.
• W2897716194 cites W2588586530 @default.
• W2897716194 cites W2752502660 @default.
• W2897716194 cites W2760061395 @default.
• W2897716194 cites W2768062840 @default.
• W2897716194 cites W2783495821 @default.
• W2897716194 cites W2802772466 @default.
• W2897716194 cites W2803862617 @default.
• W2897716194 cites W2804476437 @default.
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• W2897716194 doi "https://doi.org/10.1371/journal.pgen.1007784" @default.
• W2897716194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6391025" @default.
• W2897716194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30759082" @default.
• W2897716194 hasPublicationYear "2019" @default.
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