FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897716330> ?p ?o ?g. }

• W2897716330 abstract "The blood brain barrier (and blood-CSF barrier) (BBB) is a vital part of the brain, offering protection by providing a physical, chemical and enzymatic barrier between the blood and neuronal environment. Dysfunction of the BBB has been associated with abnormal cerebral beta-amyloid (Aß) levels and inflammatory processes that can also have downstream effects, resulting in neurodegeneration. We set out to investigate the link between CSF/plasma albumin ratio as a metric for BBB-dysfunction and CSF p-Tau as a marker of neurodegeneration and the potential role of interleukin-6 (IL-6) and Aß therein. Ninety-seven participants with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) (see figure 1 for demographics) were recruited from the memory clinic of the Maastricht University Medical Center. Biochemical analysis of CSF Aß1-42 and p-Tau181p (ELISA), serum IL-6 (cytometric bead array), CSF/plasma albumin ratio (nephelometry) and APOE genotyping was done. Data was analyzed using Spearman's rank correlation analyses and robust Huber-M mediation and moderation analyses. Moderations were probed using the Johnson-Neyman (JN) procedure to determine the region of significance at p< 0.05. All analyses were corrected for age, sex and diagnosis. Demographics Partial Spearman's rank correlations revealed that only IL-6 correlated with albumin ratio (r=0.28, p=0.006). We observed no independent effects, but a synergistic effect of IL-6 and albumin ratio on Aß (Z=-2.72, p=0.006). The JN-analyses showed that the association between albumin ratio and Aß was significant for IL-6 levels ≥3.48 pg/ml. We found no direct relation between the albumin ratio and p-Tau levels (p=0.91), but mediation analyses indicated that the mediation of Aß,on the association between BBB dysfuction and p-Tau, was contingent on elevated IL-6 levels (indirect effect for IL-6: mean-1σ (β=0.026, Z=0.075, p=0.94), mean (β=1.16, Z=1.64, p=0.09), mean+1σ (β=3.51, Z=0.197, p=0.049)). There is a negative relationship between Aß and p-Tau (p<0.001). The results suggest a link between BBB-dysfunction and markers of neurodegeneration via Aß-mediated mechanisms in the presence of elevated IL-6 levels, indicating that inflammation and BBB-dysfunction, in addition to Aß are important components in the path to neurodegeneration. These results fit with autopsy studies reporting a common co-occurrence of Aß and vascular pathology in AD-type dementia . Schematic representation of the moderated mediation results Note: Values on the arrows show the unstandardized estimates. Note that the total effect (association between BBB-dysfunction and p-Tau) was not significant. Results show that the mediation by Ab on the association between BBB-dysfunction and p-Tau was contingent on higher levels of IL6. Conditional effect of IL-6 on the association between BBB-dysfunction and Aβ Note: simple slopes between BBB-dysfunction on Aβ are plotted as a function of IL-6. The region of IL-6 values that is associated with a negative association between BBB-dysfunction on Aβ is indicated in the grey shaded region (>3.478)." @default.
• W2897716330 created "2018-10-26" @default.
• W2897716330 creator A5000291248 @default.
• W2897716330 creator A5008603484 @default.
• W2897716330 creator A5022805725 @default.
• W2897716330 creator A5032256817 @default.
• W2897716330 creator A5054596281 @default.
• W2897716330 creator A5055889988 @default.
• W2897716330 creator A5062648081 @default.
• W2897716330 date "2018-07-01" @default.
• W2897716330 modified "2023-10-16" @default.
• W2897716330 title "P3‐232: THE ASSOCIATION BETWEEN BLOOD‐BRAIN‐BARRIER DYSFUNCTION AND CSF P‐TAU IS MEDIATED BY BETA‐AMYLOID IN THE PRESENCE OF ELEVATED IL‐6" @default.
• W2897716330 doi "https://doi.org/10.1016/j.jalz.2018.06.1591" @default.
• W2897716330 hasPublicationYear "2018" @default.
• W2897716330 type Work @default.
• W2897716330 sameAs 2897716330 @default.
• W2897716330 citedByCount "0" @default.
• W2897716330 crossrefType "journal-article" @default.
• W2897716330 hasAuthorship W2897716330A5000291248 @default.
• W2897716330 hasAuthorship W2897716330A5008603484 @default.
• W2897716330 hasAuthorship W2897716330A5022805725 @default.
• W2897716330 hasAuthorship W2897716330A5032256817 @default.
• W2897716330 hasAuthorship W2897716330A5054596281 @default.
• W2897716330 hasAuthorship W2897716330A5055889988 @default.
• W2897716330 hasAuthorship W2897716330A5062648081 @default.
• W2897716330 hasConcept C126322002 @default.
• W2897716330 hasConcept C134018914 @default.
• W2897716330 hasConcept C15744967 @default.
• W2897716330 hasConcept C2776125364 @default.
• W2897716330 hasConcept C2776156579 @default.
• W2897716330 hasConcept C2776925932 @default.
• W2897716330 hasConcept C2778402981 @default.
• W2897716330 hasConcept C2779134260 @default.
• W2897716330 hasConcept C2779651940 @default.
• W2897716330 hasConcept C529278444 @default.
• W2897716330 hasConcept C57089818 @default.
• W2897716330 hasConcept C71924100 @default.
• W2897716330 hasConcept C90924648 @default.
• W2897716330 hasConceptScore W2897716330C126322002 @default.
• W2897716330 hasConceptScore W2897716330C134018914 @default.
• W2897716330 hasConceptScore W2897716330C15744967 @default.
• W2897716330 hasConceptScore W2897716330C2776125364 @default.
• W2897716330 hasConceptScore W2897716330C2776156579 @default.
• W2897716330 hasConceptScore W2897716330C2776925932 @default.
• W2897716330 hasConceptScore W2897716330C2778402981 @default.
• W2897716330 hasConceptScore W2897716330C2779134260 @default.
• W2897716330 hasConceptScore W2897716330C2779651940 @default.
• W2897716330 hasConceptScore W2897716330C529278444 @default.
• W2897716330 hasConceptScore W2897716330C57089818 @default.
• W2897716330 hasConceptScore W2897716330C71924100 @default.
• W2897716330 hasConceptScore W2897716330C90924648 @default.
• W2897716330 hasIssue "7S_Part_22" @default.
• W2897716330 hasLocation W28977163301 @default.
• W2897716330 hasOpenAccess W2897716330 @default.
• W2897716330 hasPrimaryLocation W28977163301 @default.
• W2897716330 hasRelatedWork W1825683130 @default.
• W2897716330 hasRelatedWork W2150522638 @default.
• W2897716330 hasRelatedWork W2155854266 @default.
• W2897716330 hasRelatedWork W2160510592 @default.
• W2897716330 hasRelatedWork W2266467625 @default.
• W2897716330 hasRelatedWork W2275976839 @default.
• W2897716330 hasRelatedWork W2400209006 @default.
• W2897716330 hasRelatedWork W2407574591 @default.
• W2897716330 hasRelatedWork W2410701298 @default.
• W2897716330 hasRelatedWork W2748952813 @default.
• W2897716330 hasVolume "14" @default.
• W2897716330 isParatext "false" @default.
• W2897716330 isRetracted "false" @default.
• W2897716330 magId "2897716330" @default.
• W2897716330 workType "article" @default.