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• W2897716553 startingPage "1929" @default.
• W2897716553 abstract "Prior epidemiologic findings for plasma folate and B‐vitamins and breast cancer risk are inconsistent and have not assessed the influence of folic acid fortification. Therefore, we examined the associations of plasma folate, B 12 , pyridoxal 5′‐phosphate (PLP), homocysteine, cysteine and cysteinylglycine with breast cancer risk, before and after fortification. We conducted a nested case–control study within the prospective Nurses’ Health Study. In 1989–1990 (pre‐fortification), 32,826 women donated a blood sample and 18,743 donated an additional blood sample in 2000–2001 (post‐fortification). Between the first blood collection and 2006, 1874 incident breast cancer cases with at least one blood sample and 367 with two were 1:1 matched to controls. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) adjusting for breast cancer risk factors. Overall, higher plasma folate, B 12 , PLP, homocysteine, cysteine and cysteinylglycine levels were not associated with breast cancer risk. Associations did not vary by in situ /invasive, hormone receptor status, or tumor molecular subtype. Additionally, associations were null before and after fortification. For example, the RR (95% CI) for the highest versus lowest tertile of 1990 (pre‐fortification) plasma folate with 1990–2000 follow‐up was 0.93 (0.75–1.16) and for the 2000 plasma folate (post‐fortification) with 2000–2006 follow‐up the RR (95% CI) was 1.17 (0.79–1.74). Plasma folate, B 12 , PLP, homocysteine, cysteine and cysteinylglycine were not significantly associated with breast cancer overall, before and after fortification, or with specific tumor molecular subtypes. However, long term associations (>8 years) after the implementation of fortification could not be examined." @default.
• W2897716553 created "2018-10-26" @default.
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• W2897716553 date "2019-01-03" @default.
• W2897716553 modified "2023-10-15" @default.
• W2897716553 title "Plasma B‐vitamin and one‐carbon metabolites and risk of breast cancer before and after folic acid fortification in the United States" @default.
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• W2897716553 doi "https://doi.org/10.1002/ijc.31934" @default.
• W2897716553 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7895336" @default.
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