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- W2897717830 abstract "Background: Follicular lymphoma (FL) is a typical low-grade lymphoma and there are various treatments. Standard chemotherapy, timing of initial treatment and proper relative dose intensity (RDI) have not established. Purpose and methods: This retrospective study was performed to evaluate the influence of RDI on outcome of treatment in advanced FL with R-CHOP. The average values of RDI of Cyclophosphamide (CPA), Doxorubicin (DXR) and Vincristine (VCR), respectively were used. We defined RDI ≥ 0.7 as high group (RDI-H) and RDI < 0.7 as low group (RDI-L). Results: From 2004 to 2017, a total of 96 patients were treated R-CHOP (54 RDI-H, 42 RDI-L) and the median follow-up time was 5.6 years. The mean RDI was 0.82 (RDI-H) and 0.51 (RDI-L). The median age of initial treatment was 61 (RDI-H) and 59 years(RDI-L). No correlation between age, gender, stage, Grade (WHO criteria), FLIPI, FLIPI2, tumor burden and anthracycline doses was found.No significant differences were detected in 10 years overall survival (79% vs. 79%, p = 0.88), time to treatment failure (p = 0.96) and time to next treatment (p = 0.46).These results were equivalent in the study of RDI of two agents (CPA and DXR). Conclusion: Our data indicated that outcome of advanced FL with R-CHOP was similar between RDI-H and RDI-L. Further investigations are needed for improving outcomes of FL patients due to small sample size study." @default.
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- W2897717830 date "2018-10-01" @default.
- W2897717830 modified "2023-09-26" @default.
- W2897717830 title "Impact of relative dose intensity of R-CHOP on outcomes of patients with advanced follicular lymphoma" @default.
- W2897717830 doi "https://doi.org/10.1093/annonc/mdy374.038" @default.
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