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- W2897717946 abstract "Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca2+ imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex produce a diverse and distributed representation that is required for mice to adapt their whisking motor strategy to changing sensory cues. The optogenetic perturbation degraded single-neuron selectivity and network population encoding through a selective inhibition of active dendritic integration. Together the data indicate that active dendritic integration in pyramidal neurons produces a nonlinearly mixed network representation of joint sensorimotor parameters that is used to transform sensory information into motor commands during adaptive behavior. The prevalence of the layer 5 cortical circuit motif suggests that this is a general circuit computation." @default.
- W2897717946 created "2018-10-26" @default.
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- W2897717946 date "2018-10-22" @default.
- W2897717946 modified "2023-10-18" @default.
- W2897717946 title "Active dendritic integration and mixed neocortical network representations during an adaptive sensing behavior" @default.
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- W2897717946 doi "https://doi.org/10.1038/s41593-018-0254-6" @default.
- W2897717946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203624" @default.
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