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- W2897721164 abstract "Abstract Preeclampsia is a pregnancy‐related disorder characterized by hypertension and often fetal intrauterine growth restriction, but the underlying mechanisms are unclear. Defective placentation and apoptosis of invasive cytotrophoblasts cause inadequate remodeling of spiral arteries, placental ischemia, and reduced uterine perfusion pressure ( RUPP ). RUPP causes imbalance between the anti‐angiogenic factors soluble fms‐like tyrosine kinase‐1 and soluble endoglin and the pro‐angiogenic vascular endothelial growth factor and placental growth factor, and stimulates the release of proinflammatory cytokines, hypoxia‐inducible factor, reactive oxygen species, and angiotensin AT 1 receptor agonistic autoantibodies. These circulating factors target the vascular endothelium, smooth muscle and various components of the extracellular matrix. Generalized endotheliosis in systemic, renal, cerebral, and hepatic vessels causes decreases in endothelium‐derived vasodilators such as nitric oxide, prostacyclin and hyperpolarization factor, and increases in vasoconstrictors such as endothelin‐1 and thromboxane A2. Enhanced mechanisms of vascular smooth muscle contraction, such as intracellular Ca 2+ , protein kinase C, and Rho‐kinase cause further increases in vasoconstriction. Changes in matrix metalloproteinases and extracellular matrix cause inadequate vascular remodeling and increased arterial stiffening, leading to further increases in vascular resistance and hypertension. Therapeutic options are currently limited, but understanding the molecular determinants of microvascular dysfunction could help in the design of new approaches for the prediction and management of preeclampsia." @default.
- W2897721164 created "2018-10-26" @default.
- W2897721164 creator A5024512351 @default.
- W2897721164 creator A5054286727 @default.
- W2897721164 creator A5063840461 @default.
- W2897721164 creator A5070425018 @default.
- W2897721164 creator A5089174395 @default.
- W2897721164 date "2018-11-23" @default.
- W2897721164 modified "2023-10-16" @default.
- W2897721164 title "Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia" @default.
- W2897721164 cites W136917416 @default.
- W2897721164 cites W1450090558 @default.
- W2897721164 cites W1487612715 @default.
- W2897721164 cites W1497839532 @default.
- W2897721164 cites W1511047951 @default.
- W2897721164 cites W1580649242 @default.
- W2897721164 cites W1631364723 @default.
- W2897721164 cites W1695756438 @default.
- W2897721164 cites W1713638464 @default.
- W2897721164 cites W1723558717 @default.
- W2897721164 cites W1770674522 @default.
- W2897721164 cites W1810201433 @default.
- W2897721164 cites W1825642317 @default.
- W2897721164 cites W1864679293 @default.
- W2897721164 cites W1867518600 @default.
- W2897721164 cites W1895508851 @default.
- W2897721164 cites W1904070962 @default.
- W2897721164 cites W1909822603 @default.
- W2897721164 cites W1926229312 @default.
- W2897721164 cites W1953509436 @default.
- W2897721164 cites W1964125188 @default.
- W2897721164 cites W1964249453 @default.
- W2897721164 cites W1964354023 @default.
- W2897721164 cites W1964399903 @default.
- W2897721164 cites W1965548791 @default.
- W2897721164 cites W1966284289 @default.
- W2897721164 cites W1966503539 @default.
- W2897721164 cites W1966739459 @default.
- W2897721164 cites W1967661660 @default.
- W2897721164 cites W1968165380 @default.
- W2897721164 cites W1968181166 @default.
- W2897721164 cites W1969403800 @default.
- W2897721164 cites W1971222830 @default.
- W2897721164 cites W1971506857 @default.
- W2897721164 cites W1972063020 @default.
- W2897721164 cites W1972251421 @default.
- W2897721164 cites W1972844004 @default.
- W2897721164 cites W1973528463 @default.
- W2897721164 cites W1974280379 @default.
- W2897721164 cites W1974545692 @default.
- W2897721164 cites W1974704204 @default.
- W2897721164 cites W1976256001 @default.
- W2897721164 cites W1977213375 @default.
- W2897721164 cites W1977879774 @default.
- W2897721164 cites W1979017126 @default.
- W2897721164 cites W1979799876 @default.
- W2897721164 cites W1981236313 @default.
- W2897721164 cites W1981512919 @default.
- W2897721164 cites W1982676945 @default.
- W2897721164 cites W1984026715 @default.
- W2897721164 cites W1985078087 @default.
- W2897721164 cites W1987358907 @default.
- W2897721164 cites W1987649372 @default.
- W2897721164 cites W1989366084 @default.
- W2897721164 cites W1990653503 @default.
- W2897721164 cites W1990795537 @default.
- W2897721164 cites W1990813694 @default.
- W2897721164 cites W1993920494 @default.
- W2897721164 cites W1994321258 @default.
- W2897721164 cites W1994875402 @default.
- W2897721164 cites W1995016085 @default.
- W2897721164 cites W1996487829 @default.
- W2897721164 cites W1996643854 @default.
- W2897721164 cites W1996724587 @default.
- W2897721164 cites W1997222462 @default.
- W2897721164 cites W1998799923 @default.
- W2897721164 cites W1999005255 @default.
- W2897721164 cites W1999910616 @default.
- W2897721164 cites W2000526597 @default.
- W2897721164 cites W2001252757 @default.
- W2897721164 cites W2001274041 @default.
- W2897721164 cites W2002107019 @default.
- W2897721164 cites W2004466934 @default.
- W2897721164 cites W2005539077 @default.
- W2897721164 cites W2006222096 @default.
- W2897721164 cites W2006721601 @default.
- W2897721164 cites W2007209046 @default.
- W2897721164 cites W2008236428 @default.
- W2897721164 cites W2010304520 @default.
- W2897721164 cites W2010307839 @default.
- W2897721164 cites W2010437981 @default.
- W2897721164 cites W2011766327 @default.
- W2897721164 cites W2011889575 @default.
- W2897721164 cites W2011956931 @default.
- W2897721164 cites W2014871892 @default.
- W2897721164 cites W2016239123 @default.
- W2897721164 cites W2016616010 @default.
- W2897721164 cites W2016902180 @default.
- W2897721164 cites W2016979670 @default.
- W2897721164 cites W2016996762 @default.