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- W2897722170 abstract "Type 1 diabetes mellitus (T1DM) is a chronic inflammatory disease concerning insulin-producing β-cells destroyed by the conjoined action of auto reactive T cells, inflammatory cytokines and monocytic cells. Recent proof favors crucial role of cellular autoimmunity as well as its mediators in pathogenesis and following T1DM. We aimed to investigate whether IL-1α, IL-1β, or IL-10 an easily available inflammatory marker is associated with T1DM. The onset of T1DM was accompanied with elevation serum levels of IL-1α, IL-1β, and IL-10. ROC curve revealed that IL10 > 5.95 pg/ml predicted T1DM with sensitivity and specificity of 96% and 90%, respectively. The raise of serum inflammatory cytokines such as IL-1α, IL-1β, and IL-10 of the patient may be exploited as potential markers for development of T1DM. The study proposes that level of inflammatory markers is upregulated in T1DM individual in an age-dependent manner and suggesting activation of the inflammatory immune response system." @default.
- W2897722170 created "2018-10-26" @default.
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- W2897722170 date "2018-10-23" @default.
- W2897722170 modified "2023-09-26" @default.
- W2897722170 title "Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus" @default.
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- W2897722170 doi "https://doi.org/10.1186/s42269-018-0016-3" @default.
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