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- W289772229 abstract "Abstract The recognition of dsDNA by specific antibody results in the formation of soluble immune complexes (IC) that can fix complement and therefore bind to the complement receptors of circulating cells. This entire process occurs in less than five minutes in whole blood of primates and non-primates. In primates these IC are bound to erythrocytes. However, in non-primates these IC are apparently bound to platelets. In vivo studies of circulating antibody/dsDNA IC in rabbits and guinea pigs suggest that a platelet mediated IC clearance mechanism may be operative in these animals that parallels the primate erythrocyte mediated IC clearance mechanism developed by Hebert. Furthermore, the molecular weight of the dsDNA significantly affects the nature of the binding of the IC to cells and the rate of clearance of the IC from the circulation. This finding suggests a particularly important role for dsDNA of intermediate molecular weight (ca. 100, 000 to 500, 000 Daltons) in the pathogenesis of SLE." @default.
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- W289772229 date "1985-01-01" @default.
- W289772229 modified "2023-10-14" @default.
- W289772229 title "Recognition of Dsdna by Anti-Dna Antibodies. Immune Complex Formation and Further Potential Biological Consequences" @default.
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- W289772229 doi "https://doi.org/10.1016/b978-0-08-033215-4.50057-1" @default.
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