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• W2897722343 abstract "Post-translational modifications such as glycosylation play an important role in the function of homeostatic proteins, and are critical driving factors of several diseases; however, the role of glycosylation in autoimmune hepatitis is poorly understood. Here, we established an O-GlcNAc glycosylation-deficient rat model by knocking out the Eogt gene with TALEN-mediated gene targeting. The O-GlcNAc glycosylation deficiency clearly aggravated the liver injury in concanavalin-A induced autoimmune hepatitis, and delayed self-recovery of the liver. Moreover, flow cytometry analysis demonstrated increased infiltration of CD4+ T cells in the livers of rats with O-GlcNAc glycosylation deficiency, and the normal differentiation of T regulatory cells (Tregs) in the liver to inhibit T cell infiltration could not be activated. Furthermore, in vitro experiments showed that O-GlcNAc glycosylation deficiency impaired the differentiation of Tregs to inhibit activation of the Notch signaling pathway in CD4+ T cells. This finding implies that O-GlcNAc glycosylation plays a critical role in activation of Notch signaling, which could promote the differentiation of Tregs in the liver to inhibit T cells infiltration and control disease development in autoimmune hepatitis. Therefore, this study reveals a regulatory role of glycosylation in the pathogenesis of autoimmune hepatitis, and highlights glycosylation as a potential treatment target." @default.
• W2897722343 created "2018-10-26" @default.
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• W2897722343 date "2018-10-09" @default.
• W2897722343 modified "2023-09-27" @default.
• W2897722343 title "Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis" @default.
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• W2897722343 doi "https://doi.org/10.3389/fimmu.2018.02089" @default.
• W2897722343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189470" @default.
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