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- W2897722667 abstract "In this issue of Cancer Cell, Medler et al. demonstrate that fibrinolytic enzyme-mediated generation of complement C5a reprograms tumor-infiltrating C5aR1+ macrophages into an immunosuppressive phenotype that dampens CD8+ T cell responses during squamous carcinogenesis. C5aR1 blockade combined with chemotherapy offers a promising immunomodulatory strategy for treating squamous cell carcinoma." @default.
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- W2897722667 date "2018-10-01" @default.
- W2897722667 modified "2023-10-03" @default.
- W2897722667 title "Complement C5a-Mediated TAM-ing of Antitumor Immunity Drives Squamous Carcinogenesis" @default.
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- W2897722667 doi "https://doi.org/10.1016/j.ccell.2018.09.005" @default.
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