FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897723441> ?p ?o ?g. }

• W2897723441 endingPage "2703" @default.
• W2897723441 startingPage "2677" @default.
• W2897723441 abstract "Chloroplasts import thousands of nucleus-encoded preproteins synthesized in the cytosol through the TOC and TIC translocons on the outer and inner envelope membranes, respectively. Preprotein translocation across the inner membrane requires ATP; however, the import motor has remained unclear. Here, we report that a 2-MD heteromeric AAA-ATPase complex associates with the TIC complex and functions as the import motor, directly interacting with various translocating preproteins. This 2-MD complex consists of a protein encoded by the previously enigmatic chloroplast gene ycf2 and five related nuclear-encoded FtsH-like proteins, namely, FtsHi1, FtsHi2, FtsHi4, FtsHi5, and FtsH12. These components are each essential for plant viability and retain the AAA-type ATPase domain, but only FtsH12 contains the zinc binding active site generally conserved among FtsH-type metalloproteases. Furthermore, even the FtsH12 zinc binding site is dispensable for its essential function. Phylogenetic analyses suggest that all AAA-type members of the Ycf2/FtsHi complex including Ycf2 evolved from the chloroplast-encoded membrane-bound AAA-protease FtsH of the ancestral endosymbiont. The Ycf2/FtsHi complex also contains an NAD-malate dehydrogenase, a proposed key enzyme for ATP production in chloroplasts in darkness or in nonphotosynthetic plastids. These findings advance our understanding of this ATP-driven protein translocation system that is unique to the green lineage of photosynthetic eukaryotes." @default.
• W2897723441 created "2018-10-26" @default.
• W2897723441 creator A5020057977 @default.
• W2897723441 creator A5036669991 @default.
• W2897723441 creator A5037298991 @default.
• W2897723441 creator A5050399626 @default.
• W2897723441 creator A5050980244 @default.
• W2897723441 creator A5054492162 @default.
• W2897723441 creator A5065226364 @default.
• W2897723441 creator A5068600093 @default.
• W2897723441 creator A5070488695 @default.
• W2897723441 creator A5071862675 @default.
• W2897723441 creator A5082035669 @default.
• W2897723441 creator A5085689045 @default.
• W2897723441 creator A5088998125 @default.
• W2897723441 date "2018-10-11" @default.
• W2897723441 modified "2023-10-14" @default.
• W2897723441 title "A Ycf2-FtsHi Heteromeric AAA-ATPase Complex Is Required for Chloroplast Protein Import" @default.
• W2897723441 cites W1537936159 @default.
• W2897723441 cites W1551563523 @default.
• W2897723441 cites W1587563234 @default.
• W2897723441 cites W1910267774 @default.
• W2897723441 cites W1966992670 @default.
• W2897723441 cites W1982395937 @default.
• W2897723441 cites W1995630780 @default.
• W2897723441 cites W2003691555 @default.
• W2897723441 cites W2010529756 @default.
• W2897723441 cites W2012519058 @default.
• W2897723441 cites W2012938147 @default.
• W2897723441 cites W2014036998 @default.
• W2897723441 cites W2017033636 @default.
• W2897723441 cites W2019260822 @default.
• W2897723441 cites W2019531132 @default.
• W2897723441 cites W2022934277 @default.
• W2897723441 cites W2027980348 @default.
• W2897723441 cites W2029593870 @default.
• W2897723441 cites W2053167380 @default.
• W2897723441 cites W2055949505 @default.
• W2897723441 cites W2067535938 @default.
• W2897723441 cites W2073307748 @default.
• W2897723441 cites W2081204547 @default.
• W2897723441 cites W2082513753 @default.
• W2897723441 cites W2104242013 @default.
• W2897723441 cites W2110361765 @default.
• W2897723441 cites W2114076421 @default.
• W2897723441 cites W2115127532 @default.
• W2897723441 cites W2117056672 @default.
• W2897723441 cites W2119697258 @default.
• W2897723441 cites W2119778379 @default.
• W2897723441 cites W2122831672 @default.
• W2897723441 cites W2123360519 @default.
• W2897723441 cites W2135843733 @default.
• W2897723441 cites W2138560322 @default.
• W2897723441 cites W2139280328 @default.
• W2897723441 cites W2140919652 @default.
• W2897723441 cites W2141052558 @default.
• W2897723441 cites W2144362290 @default.
• W2897723441 cites W2148698435 @default.
• W2897723441 cites W2160507690 @default.
• W2897723441 cites W2162172354 @default.
• W2897723441 cites W2164936978 @default.
• W2897723441 cites W2168959843 @default.
• W2897723441 cites W2177908500 @default.
• W2897723441 cites W2220330730 @default.
• W2897723441 cites W2228299001 @default.
• W2897723441 cites W2528576703 @default.
• W2897723441 cites W2625636492 @default.
• W2897723441 cites W2748870801 @default.
• W2897723441 cites W2765383168 @default.
• W2897723441 cites W2771454385 @default.
• W2897723441 cites W2789404437 @default.
• W2897723441 cites W2800599282 @default.
• W2897723441 cites W2809447948 @default.
• W2897723441 cites W2810410577 @default.
• W2897723441 cites W8993366 @default.
• W2897723441 doi "https://doi.org/10.1105/tpc.18.00357" @default.
• W2897723441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6305978" @default.
• W2897723441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30309901" @default.
• W2897723441 hasPublicationYear "2018" @default.
• W2897723441 type Work @default.
• W2897723441 sameAs 2897723441 @default.
• W2897723441 citedByCount "110" @default.
• W2897723441 countsByYear W28977234412018 @default.
• W2897723441 countsByYear W28977234412019 @default.
• W2897723441 countsByYear W28977234412020 @default.
• W2897723441 countsByYear W28977234412021 @default.
• W2897723441 countsByYear W28977234412022 @default.
• W2897723441 countsByYear W28977234412023 @default.
• W2897723441 crossrefType "journal-article" @default.
• W2897723441 hasAuthorship W2897723441A5020057977 @default.
• W2897723441 hasAuthorship W2897723441A5036669991 @default.
• W2897723441 hasAuthorship W2897723441A5037298991 @default.
• W2897723441 hasAuthorship W2897723441A5050399626 @default.
• W2897723441 hasAuthorship W2897723441A5050980244 @default.
• W2897723441 hasAuthorship W2897723441A5054492162 @default.
• W2897723441 hasAuthorship W2897723441A5065226364 @default.
• W2897723441 hasAuthorship W2897723441A5068600093 @default.
• W2897723441 hasAuthorship W2897723441A5070488695 @default.

• next