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- W2897726107 abstract "In the domain of tissue engineering, the repair of skeletal defects is an immediate clinical need as impaired fracture healing or nonunion bone defects often result in a functional disability for which there is no effective therapy [1].Conventional tissue engineering strategies utilize combination of biodegradable porous scaffolds and bioactive molecules such as growth factors to mimic natural processes of healing [2]. However, such approaches often produce unpredictable results, probably due to the short biological half life of bioactive molecules and lack of long term stability and tissue specificity [3]. The aim of this work is to prepare chitosan-gelatin (CH/G) scaffolds embedded with PLGA nanoparticles for the purpose of localized growth factor delivery at a pre-determined rate and to improve the therapeutic efficiency of scaffolds by mimicking the endogenous release of bioactive substance(s). Results and discussion" @default.
- W2897726107 created "2018-10-26" @default.
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- W2897726107 date "2010-01-01" @default.
- W2897726107 modified "2023-09-26" @default.
- W2897726107 title "Porous chitosan-gelatin scaffolds embedded with PLGA nanoparticles for bone repair." @default.
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