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- W2897726216 abstract "Actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) are two of the most common dermatologic conditions in Western countries and cause substantial morbidity worldwide. The role of human papillomaviruses under these conditions has been well studied yet remains inconclusive. One PCR-based study has investigated bacteria in the etiology of these conditions; however, no study has investigated the microbiomes of AK and SCC more broadly. We longitudinally profiled the microbiomes of 112 AK lesions, profiled cross sections of 32 spontaneously arising SCC lesions, and compared these to matching nonlesional photodamaged control skin sites. We identified commonly occurring strains of Propionibacterium and Malassezia at higher relative abundances on nonlesional skin than in AK and SCC lesions, and strains of Staphylococcus aureus were relatively more abundant in lesional than nonlesional skin. These findings may aid in the prevention of SCC." @default.
- W2897726216 created "2018-10-26" @default.
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- W2897726216 date "2018-11-07" @default.
- W2897726216 modified "2023-10-03" @default.
- W2897726216 title "A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes" @default.
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- W2897726216 doi "https://doi.org/10.1128/mbio.01432-18" @default.
- W2897726216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6178618" @default.
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