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- W2897727299 abstract "Prior investigations evaluating associations between APOE ε4 carriage (ε4+) and normal cognitive function in late life used relatively small samples. Few studies have large samples of well-phenotyped older ε4+ carriers to evaluate characteristics associated with cognitive resilience, defined here as reaching age 80 without cognitive impairment (CI). We compared the characteristics of cognitively healthy ε4+ women who survived to age 80 without CI to ε4+ women who developed CI before 80. We also compared ε4+ women who survived to age 80 free of CI to women with other genotypes (ε4-) who also survived to age 80 without CI. Women were recruited from 1994-1998 to participate in clinical trials evaluating effects of post-menopausal hormone therapy on incidence of all-cause dementia. Women were randomized to conjugated equine estrogens, alone or combined with medroxyprogesterone acetate, or their respective placebo. Annual follow-up evaluations continue to review health events, risk factors, and cognitive status as adjudicated by an expert panel. APOE genotypes were determined for 5716 women. We compared groups using logistic regression, with covariates for treatment arm and demographics, lifestyle, cardiovascular and physical function, well-being, and self-rated general health. 623 ε4+ women survived to age 80 without CI. They had a higher self-rating of general health (p=0.0008) and higher baseline cognitive scores (p<.0001) than ε4+ women (n=106) who did not survive to age 80 without CI. History of high cholesterol and baseline LDL levels were similar across the ε4+ groups, but were higher compared with ε4- women. Across all women who survived to age 80 without CI, ε4+ women were more likely than ε4- women, to have a history of high cholesterol (p=0.003) and higher baseline LDL cholesterol levels (p<0.0001). However, ε4+ women were not significantly more likely to have hypertension, diabetes, or other vascular risk factors associated with CI. These results highlight the importance of better cognitive function and general health as characteristics of late-life cognitive resilience among at-risk, ε4+ women. Future studies should evaluate whether the finding of high cholesterol among ε4+ carriers is due to health surveillance, medication usage, or etiological factors." @default.
- W2897727299 created "2018-10-26" @default.
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- W2897727299 date "2018-07-01" @default.
- W2897727299 modified "2023-10-16" @default.
- W2897727299 title "P1‐632: CHARACTERISTICS OF COGNITIVE RESILIENCE IN <i>APOE</i> ε4 CARRIERS AGED 80 AND OLDER: THE WOMEN'S HEALTH INITIATIVE MEMORY STUDY" @default.
- W2897727299 doi "https://doi.org/10.1016/j.jalz.2018.06.644" @default.
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