FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897729667> ?p ?o ?g. }

• W2897729667 endingPage "614" @default.
• W2897729667 startingPage "605" @default.
• W2897729667 abstract "The vast majority of polymorphisms for human dermatologic diseases fall in noncoding DNA regions, leading to difficulty interpreting their functional significance. Recent work using chromosome conformation capture technology in combination with chromatin immunoprecipitation (ChIP) has provided a systematic means of linking noncoding variants in active enhancer loci to putative gene targets. Here, we apply H3K27ac HiChIP high-resolution contact maps, generated from primary human T-cell subsets (CD4+ naïve, T helper type 17, and regulatory T cells), to 21 dermatologic conditions associated with single nucleotide polymorphisms from 106 genome-wide association studies. This “enhancer connectome” identified 1,492 HiChIP gene targets from 542 noncoding SNPs (P ≤ 5.0 × 10–8). SNP-containing enhancers from inflammatory skin conditions were significantly enriched at the HLA locus and also targeted several key factors from the JAK-STAT signaling pathway, but nonimmune conditions were not. A focused profiling of systemic lupus erythematosus HiChIP genes identified enhancer interactions with factors important for effector CD4+ T-cell differentiation and function, including IRF8 and members of the Ikaros family of zinc-finger proteins. Our results show the ability of the enhancer connectome to nominate functionally relevant candidates from genome-wide association study–identified variants, representing a powerful tool to guide future studies into the genomic regulatory mechanisms underlying dermatologic diseases. The vast majority of polymorphisms for human dermatologic diseases fall in noncoding DNA regions, leading to difficulty interpreting their functional significance. Recent work using chromosome conformation capture technology in combination with chromatin immunoprecipitation (ChIP) has provided a systematic means of linking noncoding variants in active enhancer loci to putative gene targets. Here, we apply H3K27ac HiChIP high-resolution contact maps, generated from primary human T-cell subsets (CD4+ naïve, T helper type 17, and regulatory T cells), to 21 dermatologic conditions associated with single nucleotide polymorphisms from 106 genome-wide association studies. This “enhancer connectome” identified 1,492 HiChIP gene targets from 542 noncoding SNPs (P ≤ 5.0 × 10–8). SNP-containing enhancers from inflammatory skin conditions were significantly enriched at the HLA locus and also targeted several key factors from the JAK-STAT signaling pathway, but nonimmune conditions were not. A focused profiling of systemic lupus erythematosus HiChIP genes identified enhancer interactions with factors important for effector CD4+ T-cell differentiation and function, including IRF8 and members of the Ikaros family of zinc-finger proteins. Our results show the ability of the enhancer connectome to nominate functionally relevant candidates from genome-wide association study–identified variants, representing a powerful tool to guide future studies into the genomic regulatory mechanisms underlying dermatologic diseases." @default.
• W2897729667 created "2018-10-26" @default.
• W2897729667 creator A5019319568 @default.
• W2897729667 creator A5033488040 @default.
• W2897729667 creator A5039614634 @default.
• W2897729667 creator A5040230088 @default.
• W2897729667 creator A5044978994 @default.
• W2897729667 creator A5055604014 @default.
• W2897729667 date "2019-03-01" @default.
• W2897729667 modified "2023-09-26" @default.
• W2897729667 title "Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders" @default.
• W2897729667 cites W1605145036 @default.
• W2897729667 cites W1883582022 @default.
• W2897729667 cites W1974666461 @default.
• W2897729667 cites W1982085112 @default.
• W2897729667 cites W1997691172 @default.
• W2897729667 cites W1999218213 @default.
• W2897729667 cites W2001280003 @default.
• W2897729667 cites W2007888464 @default.
• W2897729667 cites W2009155901 @default.
• W2897729667 cites W2015345028 @default.
• W2897729667 cites W2019232525 @default.
• W2897729667 cites W2032033112 @default.
• W2897729667 cites W2036209857 @default.
• W2897729667 cites W2037886921 @default.
• W2897729667 cites W2050642571 @default.
• W2897729667 cites W2055082742 @default.
• W2897729667 cites W2056198580 @default.
• W2897729667 cites W2059075557 @default.
• W2897729667 cites W2059412913 @default.
• W2897729667 cites W2063209252 @default.
• W2897729667 cites W2070021921 @default.
• W2897729667 cites W2075944172 @default.
• W2897729667 cites W2076154138 @default.
• W2897729667 cites W2094823633 @default.
• W2897729667 cites W2099495167 @default.
• W2897729667 cites W2100276321 @default.
• W2897729667 cites W2112673809 @default.
• W2897729667 cites W2113051722 @default.
• W2897729667 cites W2114044656 @default.
• W2897729667 cites W2118448966 @default.
• W2897729667 cites W2129247811 @default.
• W2897729667 cites W2136078375 @default.
• W2897729667 cites W2142270559 @default.
• W2897729667 cites W2152841034 @default.
• W2897729667 cites W2158217645 @default.
• W2897729667 cites W2160076049 @default.
• W2897729667 cites W2166026190 @default.
• W2897729667 cites W2185693210 @default.
• W2897729667 cites W2342127666 @default.
• W2897729667 cites W2401985889 @default.
• W2897729667 cites W2467933133 @default.
• W2897729667 cites W2481029670 @default.
• W2897729667 cites W2504534335 @default.
• W2897729667 cites W2519385241 @default.
• W2897729667 cites W2535910303 @default.
• W2897729667 cites W2548580472 @default.
• W2897729667 cites W2553838260 @default.
• W2897729667 cites W2587589680 @default.
• W2897729667 cites W2593684819 @default.
• W2897729667 cites W2606131188 @default.
• W2897729667 cites W2608171249 @default.
• W2897729667 cites W2618322398 @default.
• W2897729667 cites W2756125767 @default.
• W2897729667 cites W2766886761 @default.
• W2897729667 cites W2952947531 @default.
• W2897729667 cites W895824433 @default.
• W2897729667 doi "https://doi.org/10.1016/j.jid.2018.09.011" @default.
• W2897729667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315781" @default.
• W2897729667 hasPublicationYear "2019" @default.
• W2897729667 type Work @default.
• W2897729667 sameAs 2897729667 @default.
• W2897729667 citedByCount "19" @default.
• W2897729667 countsByYear W28977296672019 @default.
• W2897729667 countsByYear W28977296672020 @default.
• W2897729667 countsByYear W28977296672021 @default.
• W2897729667 countsByYear W28977296672022 @default.
• W2897729667 crossrefType "journal-article" @default.
• W2897729667 hasAuthorship W2897729667A5019319568 @default.
• W2897729667 hasAuthorship W2897729667A5033488040 @default.
• W2897729667 hasAuthorship W2897729667A5039614634 @default.
• W2897729667 hasAuthorship W2897729667A5040230088 @default.
• W2897729667 hasAuthorship W2897729667A5044978994 @default.
• W2897729667 hasAuthorship W2897729667A5055604014 @default.
• W2897729667 hasBestOaLocation W28977296671 @default.
• W2897729667 hasConcept C101762097 @default.
• W2897729667 hasConcept C104317684 @default.
• W2897729667 hasConcept C111936080 @default.
• W2897729667 hasConcept C117717151 @default.
• W2897729667 hasConcept C134320426 @default.
• W2897729667 hasConcept C135763542 @default.
• W2897729667 hasConcept C141231307 @default.
• W2897729667 hasConcept C150194340 @default.
• W2897729667 hasConcept C153209595 @default.
• W2897729667 hasConcept C190727270 @default.
• W2897729667 hasConcept C197077220 @default.
• W2897729667 hasConcept C54355233 @default.
• W2897729667 hasConcept C64554109 @default.

• next