Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897730229> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2897730229 abstract "The glymphatic clearance system is a brain-wide pathway for removal of waste solutes, which depends upon the presence of aquaporin-4 (AQP4) channels, on the endfeet of paravascular astrocytes in the brain (Iliff, et al. (2012)). Glymphatic function has been shown to be impaired in mouse models of Alzheimer's disease (AD) (Harrison et al., (2016), Peng et al., (2016)), and both amyloid-β (Iliff et al., 2012) and tau (Iliff et al., 2014) have been shown to be cleared from the brain via this system. Until now however, it is unknown whether the glymphatic pathway presents as a suitable drug target. Here we demonstrate that a novel AQP4 inhibitor, TGN-020, suppresses glymphatic function and clearance of tau from the brain, suggesting that pharmacological manipulation of AQP4 function may present as a novel drug target for the treatment of AD. Mice were treated with either AQP4 inhibitor (TGN-020) or vehicle 15mins prior to either, 1) quantification of glymphatic inflow via dynamic contrast-enhanced MRI (intracisternal administration of MRI contrast agent (Gd-DTPA) and concurrent acquisition of whole brain T1-weighted MR images (figure 2a)), or 2) assessment of parenchymal tau clearance (intracerebral infusion of tau-containing brain homogenate and subsequent cerebrospinal fluid collection (figure 2c)). Glymphatic inflow of Gd-DTPA into the parenchyma was significantly ablated after TGN-020 (figure 1 and 2b). Furthermore, intrastriatal infusion of tau-containing brain homogenate revealed that TGN-020 treatment significantly reduced tau clearance from the brain (figure 2d). Comparable TGN-020 induced inhibition of parenchymal inflow of MR contrast agent, and clearance of tau from the brain were observed (table 1), suggestive that TGN-020 inhibits arterial and venous associated AQP4 equally." @default.
- W2897730229 created "2018-10-26" @default.
- W2897730229 creator A5013599788 @default.
- W2897730229 creator A5030599902 @default.
- W2897730229 creator A5032108660 @default.
- W2897730229 creator A5050474161 @default.
- W2897730229 creator A5069588829 @default.
- W2897730229 creator A5072120186 @default.
- W2897730229 date "2018-07-01" @default.
- W2897730229 modified "2023-10-16" @default.
- W2897730229 title "IC‐P‐027: PHARMACOLOGICAL BLOCKADE OF AQUAPORIN‐4 INHIBITS GLYMPHATIC FLOW AND CLEARANCE OF TAU FROM THE MOUSE BRAIN" @default.
- W2897730229 doi "https://doi.org/10.1016/j.jalz.2018.06.2091" @default.
- W2897730229 hasPublicationYear "2018" @default.
- W2897730229 type Work @default.
- W2897730229 sameAs 2897730229 @default.
- W2897730229 citedByCount "0" @default.
- W2897730229 crossrefType "journal-article" @default.
- W2897730229 hasAuthorship W2897730229A5013599788 @default.
- W2897730229 hasAuthorship W2897730229A5030599902 @default.
- W2897730229 hasAuthorship W2897730229A5032108660 @default.
- W2897730229 hasAuthorship W2897730229A5050474161 @default.
- W2897730229 hasAuthorship W2897730229A5069588829 @default.
- W2897730229 hasAuthorship W2897730229A5072120186 @default.
- W2897730229 hasConcept C101054994 @default.
- W2897730229 hasConcept C126894567 @default.
- W2897730229 hasConcept C138944611 @default.
- W2897730229 hasConcept C142724271 @default.
- W2897730229 hasConcept C15744967 @default.
- W2897730229 hasConcept C15755913 @default.
- W2897730229 hasConcept C169760540 @default.
- W2897730229 hasConcept C185592680 @default.
- W2897730229 hasConcept C196822366 @default.
- W2897730229 hasConcept C2779651940 @default.
- W2897730229 hasConcept C71924100 @default.
- W2897730229 hasConcept C98274493 @default.
- W2897730229 hasConceptScore W2897730229C101054994 @default.
- W2897730229 hasConceptScore W2897730229C126894567 @default.
- W2897730229 hasConceptScore W2897730229C138944611 @default.
- W2897730229 hasConceptScore W2897730229C142724271 @default.
- W2897730229 hasConceptScore W2897730229C15744967 @default.
- W2897730229 hasConceptScore W2897730229C15755913 @default.
- W2897730229 hasConceptScore W2897730229C169760540 @default.
- W2897730229 hasConceptScore W2897730229C185592680 @default.
- W2897730229 hasConceptScore W2897730229C196822366 @default.
- W2897730229 hasConceptScore W2897730229C2779651940 @default.
- W2897730229 hasConceptScore W2897730229C71924100 @default.
- W2897730229 hasConceptScore W2897730229C98274493 @default.
- W2897730229 hasIssue "7S_Part_1" @default.
- W2897730229 hasLocation W28977302291 @default.
- W2897730229 hasOpenAccess W2897730229 @default.
- W2897730229 hasPrimaryLocation W28977302291 @default.
- W2897730229 hasRelatedWork W2397614738 @default.
- W2897730229 hasRelatedWork W2559874802 @default.
- W2897730229 hasRelatedWork W2767482362 @default.
- W2897730229 hasRelatedWork W2790746777 @default.
- W2897730229 hasRelatedWork W2903837608 @default.
- W2897730229 hasRelatedWork W4205821242 @default.
- W2897730229 hasRelatedWork W4282038963 @default.
- W2897730229 hasRelatedWork W4353055828 @default.
- W2897730229 hasRelatedWork W4385544083 @default.
- W2897730229 hasRelatedWork W4387216896 @default.
- W2897730229 hasVolume "14" @default.
- W2897730229 isParatext "false" @default.
- W2897730229 isRetracted "false" @default.
- W2897730229 magId "2897730229" @default.
- W2897730229 workType "article" @default.