FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897732426> ?p ?o ?g. }

• W2897732426 endingPage "197" @default.
• W2897732426 startingPage "191" @default.
• W2897732426 abstract "Abstract The lipopolysaccharide (LPS) and d -galactosamine (D-GalN)-induced hepatotoxicity is a classical model to elucidate the mechanisms and explore potential therapeutic drugs for fulminant hepatic failure (FHF). γ-Oryzanol (γ-ORY) has been showed to possess both antioxidant and anti-inflammatory properties in several pathological models. However, it remains unclear whether γ-ORY could protect against LPS/D-GalN-induced hepatotoxicity. Thus, the aim of the current study was to evaluate the effects of γ-ORY supplementation (for 7 consecutive days) in LPS/D-GalN-induced FHF in mice. One hour after the last supplementation with γ-ORY, the animals received LPS/D-GalN (50 and 500 mg/kg, respectively; i.p.). Twenty-four hours after LPS/D-GalN administration, biochemical assays were performed. LPS/D-GalN administration caused severe histological damage in the liver, such as vascular congestion and megalocytosis, as well as elicited hepatic failure. LPS/D-GalN treatment also caused alterations in liver function, increased levels of oxidative stress and inflammatory markers. In contrast, γ-ORY supplementation protected against histological, oxidative and inflammatory alterations induced by LPS/D-GalN exposure. Collectively, our data supports the notion that both oxidative stress and inflammatory responses are two key pathogenic factors that contribute to LPS/D-GaIN-mediated FHF. Due to its antioxidant and anti-inflammatory actions, our study indicates γ-ORY as a putative pharmacological option to prevent LPS/D-GalN-induced hepatotoxicity." @default.
• W2897732426 created "2018-10-26" @default.
• W2897732426 creator A5001791903 @default.
• W2897732426 creator A5003276408 @default.
• W2897732426 creator A5009423426 @default.
• W2897732426 creator A5017526675 @default.
• W2897732426 creator A5021903833 @default.
• W2897732426 creator A5030179452 @default.
• W2897732426 creator A5035841322 @default.
• W2897732426 creator A5044324691 @default.
• W2897732426 creator A5050065227 @default.
• W2897732426 creator A5070543038 @default.
• W2897732426 creator A5079224102 @default.
• W2897732426 date "2018-12-01" @default.
• W2897732426 modified "2023-09-26" @default.
• W2897732426 title "γ-Oryzanol supplementation modifies the inflammatory and oxidative response in fulminant hepatic failure in mice" @default.
• W2897732426 cites W1122013619 @default.
• W2897732426 cites W1581414347 @default.
• W2897732426 cites W1750690213 @default.
• W2897732426 cites W182540526 @default.
• W2897732426 cites W191793640 @default.
• W2897732426 cites W1969415522 @default.
• W2897732426 cites W1977628259 @default.
• W2897732426 cites W1983310681 @default.
• W2897732426 cites W1989755066 @default.
• W2897732426 cites W1992506941 @default.
• W2897732426 cites W1997173726 @default.
• W2897732426 cites W1997660418 @default.
• W2897732426 cites W2006370393 @default.
• W2897732426 cites W2006910940 @default.
• W2897732426 cites W2007955652 @default.
• W2897732426 cites W2015036056 @default.
• W2897732426 cites W2031784846 @default.
• W2897732426 cites W2038982079 @default.
• W2897732426 cites W2048203983 @default.
• W2897732426 cites W2052445471 @default.
• W2897732426 cites W2055869203 @default.
• W2897732426 cites W2058392826 @default.
• W2897732426 cites W2061301430 @default.
• W2897732426 cites W2061643619 @default.
• W2897732426 cites W2077577005 @default.
• W2897732426 cites W2080279300 @default.
• W2897732426 cites W2085215147 @default.
• W2897732426 cites W2089049066 @default.
• W2897732426 cites W2091867263 @default.
• W2897732426 cites W2092289140 @default.
• W2897732426 cites W2093722569 @default.
• W2897732426 cites W2106704952 @default.
• W2897732426 cites W2115434459 @default.
• W2897732426 cites W2116342732 @default.
• W2897732426 cites W2140220916 @default.
• W2897732426 cites W2143263732 @default.
• W2897732426 cites W2144199622 @default.
• W2897732426 cites W2155772701 @default.
• W2897732426 cites W2157277055 @default.
• W2897732426 cites W2162270805 @default.
• W2897732426 cites W2197332903 @default.
• W2897732426 cites W2400418602 @default.
• W2897732426 cites W384075993 @default.
• W2897732426 cites W4245492773 @default.
• W2897732426 cites W4255712601 @default.
• W2897732426 cites W4293247451 @default.
• W2897732426 doi "https://doi.org/10.1016/j.phanu.2018.10.002" @default.
• W2897732426 hasPublicationYear "2018" @default.
• W2897732426 type Work @default.
• W2897732426 sameAs 2897732426 @default.
• W2897732426 citedByCount "6" @default.
• W2897732426 countsByYear W28977324262019 @default.
• W2897732426 countsByYear W28977324262020 @default.
• W2897732426 crossrefType "journal-article" @default.
• W2897732426 hasAuthorship W2897732426A5001791903 @default.
• W2897732426 hasAuthorship W2897732426A5003276408 @default.
• W2897732426 hasAuthorship W2897732426A5009423426 @default.
• W2897732426 hasAuthorship W2897732426A5017526675 @default.
• W2897732426 hasAuthorship W2897732426A5021903833 @default.
• W2897732426 hasAuthorship W2897732426A5030179452 @default.
• W2897732426 hasAuthorship W2897732426A5035841322 @default.
• W2897732426 hasAuthorship W2897732426A5044324691 @default.
• W2897732426 hasAuthorship W2897732426A5050065227 @default.
• W2897732426 hasAuthorship W2897732426A5070543038 @default.
• W2897732426 hasAuthorship W2897732426A5079224102 @default.
• W2897732426 hasConcept C126322002 @default.
• W2897732426 hasConcept C203014093 @default.
• W2897732426 hasConcept C2776151105 @default.
• W2897732426 hasConcept C2776914184 @default.
• W2897732426 hasConcept C2779609443 @default.
• W2897732426 hasConcept C2781107259 @default.
• W2897732426 hasConcept C2911091166 @default.
• W2897732426 hasConcept C2911118192 @default.
• W2897732426 hasConcept C3020196126 @default.
• W2897732426 hasConcept C55493867 @default.
• W2897732426 hasConcept C57600042 @default.
• W2897732426 hasConcept C71924100 @default.
• W2897732426 hasConcept C86803240 @default.
• W2897732426 hasConceptScore W2897732426C126322002 @default.
• W2897732426 hasConceptScore W2897732426C203014093 @default.
• W2897732426 hasConceptScore W2897732426C2776151105 @default.
• W2897732426 hasConceptScore W2897732426C2776914184 @default.

• next