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- W2897732973 abstract "Aim: Nanoparticle-based photosensitizers containing silver core and mesoporous silica shell with hematoporphyrin IX embedded were developed to treat vulgaris photodynamically. Materials & methods: The hybrid photosensitizers were dispersed in 30% polyethylene glycol (PEG-200) solution and used for the photodynamic treatment of Staphylococcus epidermidis and Propionibacterium acnes under the illumination of a portable LED (∼410 nm). Results: After a 5 min illumination by the LED, the hybrid photosensitizers of 50 μg/ml displayed killing efficacy of approximately 5-log for S. epidermidis and approximately 4-log for P. acnes. Results indicated that hybrid photosensitizers in PEG-200 matrix perform better than in deionized (DI) water (∼1-log increase in killing efficacy).Conclusion: Under short illumination of a portable LED, hybrid photosensitizers demonstrated immense potential for treatment of acne vulgaris without involving antibiotics." @default.
- W2897732973 created "2018-10-26" @default.
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- W2897732973 date "2018-10-01" @default.
- W2897732973 modified "2023-10-16" @default.
- W2897732973 title "Highly efficient and biocompatible nanoparticle-based photosensitizer for treatment of acne vulgaris" @default.
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- W2897732973 doi "https://doi.org/10.2217/nnm-2018-0125" @default.
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